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    fech ferrochelatase [ Danio rerio (zebrafish) ]

    Gene ID: 58215, updated on 27-Dec-2024

    Summary

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    Official Symbol
    fechprovided by ZNC
    Official Full Name
    ferrochelataseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000928-1
    See related
    Ensembl:ENSDARG00000003462 AllianceGenome:ZFIN:ZDB-GENE-000928-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fch; zgc:109851
    Summary
    Enables ferrochelatase activity. Acts upstream of or within erythrocyte maturation. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in blood; intermediate cell mass of mesoderm; kidney; posterior lateral plate mesoderm; and ventral mesoderm. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fech in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (1647915..1671436)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (1622195..1644440)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene vitelline membrane outer layer 1 homolog b Neighboring gene zgc:152948 Neighboring gene one cut homeobox 2 Neighboring gene uncharacterized LOC103909387

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity. Gupta V, et al. Mol Pharmacol, 2013 Dec. PMID 24043703
    2. Morpholino phosphorodiamidate oligonucleotides in zebrafish: a recipe for functional genomics? Sumanas S, et al. Brief Funct Genomic Proteomic, 2002 Oct. PMID 15239891
    3. Hematopoietic mutations in the zebrafish. Weinstein BM, et al. Development, 1996 Dec. PMID 9007250
    4. Molecular evolution and expression of zebrafish St8SiaIII, an alpha-2,8-sialyltransferase involved in myotome development. Bentrop J, et al. Dev Dyn, 2008 Mar. PMID 18265011
    5. Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. Shah DI, et al. Nature, 2012 Nov 22. PMID 23135403, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC109851

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ferrochelatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrochelatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrochelatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within erythrocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within porphyrin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ferrochelatase, mitochondrial
    Names
    dracula
    drc
    frx
    NP_571706.1
    XP_021324574.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131631.2 → NP_571706.1  ferrochelatase, mitochondrial

      See identical proteins and their annotated locations for NP_571706.1

      Status: PROVISIONAL

      Source sequence(s)
      AF250368
      UniProtKB/TrEMBL
      Q9DFU9
      Related
      ENSDARP00000125028.1, ENSDART00000148540.2
      Conserved Domains (3) summary
      cd00419
      Location:221 → 358
      Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
      cd03411
      Location:55 → 216
      Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
      pfam00762
      Location:55 → 375
      Ferrochelatase; Ferrochelatase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      1647915..1671436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468899.2 → XP_021324574.1  ferrochelatase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8M9PIE9
      Conserved Domains (1) summary
      pfam00762
      Location:55 → 375
      Ferrochelatase
    Nucleotide Protein
    Heading Accession and Version

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