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    scp2a sterol carrier protein 2a [ Danio rerio (zebrafish) ]

    Gene ID: 393839, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scp2aprovided by ZNC
    Official Full Name
    sterol carrier protein 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1846
    See related
    Ensembl:ENSDARG00000012194 AllianceGenome:ZFIN:ZDB-GENE-040426-1846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    scp2; zgc:77634
    Summary
    Predicted to enable C-acyltransferase activity; lipid binding activity; and propionyl-CoA C2-trimethyltridecanoyltransferase activity. Predicted to act upstream of or within lipid transport. Predicted to be located in mitochondrion. Predicted to be active in peroxisome. Is expressed in intestinal bulb; lens; liver; and solid lens vesicle. Orthologous to human SCP2 (sterol carrier protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See scp2a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (6005199..6039741, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (6093317..6127859, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 125b Neighboring gene solute carrier family 1 member 7a Neighboring gene CXXC motif containing zinc binding protein Neighboring gene uridine-cytidine kinase 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Slc25a17 acts as a peroxisomal coenzyme A transporter and regulates multiorgan development in zebrafish. Kim YI, et al. J Cell Physiol, 2020 Jan. PMID 31187491
    2. Hepatotoxicity assessment of Rhizoma Paridis in adult zebrafish through proteomes and metabolome. Jia Z, et al. Biomed Pharmacother, 2020 Jan. PMID 31766101
    3. Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - The role of Hsp90. Pfeiffer J, et al. Dev Biol, 2018 Apr 15. PMID 29477339
    4. Proteomic analysis of arsenic-exposed zebrafish (Danio rerio) identifies altered expression in proteins involved in fibrosis and lipid uptake in a gender-specific manner. Carlson P, et al. Toxicol Sci, 2013 Jul. PMID 23570992
    5. Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma. Zheng W, et al. PLoS One, 2014. PMID 24633177, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC77634

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acetyl-CoA C-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetyl-CoA C-myristoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables propanoyl-CoA C-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables propionyl-CoA C2-trimethyltridecanoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sterol carrier protein 2
    NP_957159.1
    XP_005163287.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200865.2 → NP_957159.1  sterol carrier protein 2

      See identical proteins and their annotated locations for NP_957159.1

      Status: VALIDATED

      Source sequence(s)
      BC063230, EB893297
      UniProtKB/TrEMBL
      A0A8M1PDK4, Q6P4V5
      Related
      ENSDARP00000009052.7, ENSDART00000013079.9
      Conserved Domains (3) summary
      PRK08256
      Location:6 → 397
      PRK08256; lipid-transfer protein; Provisional
      cd00826
      Location:11 → 396
      nondecarbox_cond_enzymes; nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. There are 2 ...
      pfam02036
      Location:428 → 529
      SCP2; SCP-2 sterol transfer family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      6005199..6039741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163230.3 → XP_005163287.2  sterol carrier protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BA96
      Conserved Domains (2) summary
      pfam02036
      Location:222 → 323
      SCP2; SCP-2 sterol transfer family
      cl27752
      Location:1 → 191
      PRK06064; acetyl-CoA acetyltransferase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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