rfc1 replication factor C (activator 1) 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rfc1provided by ZNC
Official Full Name: replication factor C (activator 1) 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-070410-99
See related: Ensembl:ENSDARG00000054799 AllianceGenome:ZFIN:ZDB-GENE-070410-99
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:162875; si:dkey-170e5.1
Summary: Predicted to enable DNA binding activity and DNA clamp unloader activity. Predicted to be involved in anatomical structure morphogenesis. Predicted to act upstream of or within DNA repair and DNA replication. Predicted to be part of DNA replication factor C complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in West Nile fever and congenital heart disease. Orthologous to human RFC1 (replication factor C subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (23243043..23268569, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (22552304..22577830, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp unloader activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of DNA replication factor C complex	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: replication factor C subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089491.2 → NP_001082960.2 replication factor C subunit 1

Status: VALIDATED

Source sequence(s)

BX000461, CR759875

UniProtKB/TrEMBL

A0A8M1NED6, F1Q5P6, F1QTJ0

Related

ENSDARP00000113369.1, ENSDART00000143948.3

Conserved Domains (4) summary

PRK04195
Location:576 → 1131

PRK04195; replication factor C large subunit; Provisional

cd00027
Location:405 → 476

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

pfam00004
Location:641 → 768

AAA; ATPase family associated with various cellular activities (AAA)

pfam08519
Location:907 → 1060

RFC1; Replication factor RFC1 C terminal domain