cemip2 cell migration inducing hyaluronidase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cemip2provided by ZNC
Official Full Name: cell migration inducing hyaluronidase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2179
See related: Ensembl:ENSDARG00000061600 AllianceGenome:ZFIN:ZDB-GENE-030131-2179
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tmem2; fa98g01; fb99a08; wu:fa98g01; wu:fb99a08; si:dkey-24k20.1
Summary: Enables hyalurononglucosaminidase activity. Involved in several processes, including heart development; hyaluronan catabolic process; and regulation of signal transduction. Acts upstream of or within heart development; muscle attachment; and positive regulation of extracellular matrix assembly. Located in plasma membrane. Is expressed in brain; cardiovascular system; fin bud; head mesenchyme; and otic vesicle. Orthologous to human CEMIP2 (cell migration inducing hyaluronidase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (25760190..25813615)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (25160006..25213463)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A model in which hyaluronic acid degradation, regulated by Tmem2, limits the distribution of Wnt signaling and thereby confines the differentiation of the Atrioventricular Canal.
Title: Tmem2 restricts atrioventricular canal differentiation by regulating degradation of hyaluronic acid.
Tmem2 regulates hyaluronic acid turnover to promote normal Vegf signaling during developmental angiogenesis.
Title: Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.
Tmem2 is an essential mediator of myocardium-endocardium coordination during cardiac morphogenesis
Title: The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis.
immature AVC expansion in wkm mutants is rescued by depleting Bmp4, indicating that Tmem2 restricts bmp4 expression to delimit the AVC primordium during cardiac development
Title: Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development.

Submit: New GeneRIF Correction

General gene information

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Markers

fa98g01 (e-PCR)
- UniSTS:188944

fb99a08.x1 (e-PCR)
- UniSTS:187675

fc55f05.y1 (e-PCR)
- UniSTS:194079

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables hyalurononglucosaminidase activity	IDA Inferred from Direct Assay more info	PubMed
enables hyalurononglucosaminidase activity	IEA Inferred from Electronic Annotation more info
enables hyalurononglucosaminidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in atrioventricular valve formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration involved in heart formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration to the midline involved in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic heart tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocardial cushion development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyaluronan catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hyaluronan catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of extracellular matrix assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular endothelial growth factor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of vascular endothelial growth factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell surface hyaluronidase

Names: frozen ventricle; frv; protein frozen ventricle; protein wickham; transmembrane protein 2

NP_001092919.1

EC 3.2.1.35

XP_005171957.1

EC 3.2.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099449.1 → NP_001092919.1 cell surface hyaluronidase

See identical proteins and their annotated locations for NP_001092919.1

Status: PROVISIONAL

Source sequence(s)

BX294191

UniProtKB/Swiss-Prot

A3KPQ7

Related

ENSDARP00000118976.1, ENSDART00000133217.2

Conserved Domains (3) summary

cd13938
Location:222 → 389

PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2

pfam10162
Location:122 → 246

G8; G8 domain

pfam15711
Location:1239 → 1327

ILEI; Interleukin-like EMT inducer

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

25760190..25813615

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005171900.5 → XP_005171957.1 cell surface hyaluronidase isoform X1

See identical proteins and their annotated locations for XP_005171957.1

UniProtKB/TrEMBL

A0A8M2BJ92, G0ZDN6

Related

ENSDARP00000082444.4, ENSDART00000088011.7

Conserved Domains (3) summary

cd13938
Location:222 → 389

PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2

pfam10162
Location:122 → 246

G8; G8 domain

pfam15711
Location:1251 → 1339

ILEI; Interleukin-like EMT inducer