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    hnrnpua heterogeneous nuclear ribonucleoprotein Ua [ Danio rerio (zebrafish) ]

    Gene ID: 566326, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hnrnpuaprovided by ZNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Uaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3731
    See related
    Ensembl:ENSDARG00000015206 AllianceGenome:ZFIN:ZDB-GENE-030131-3731
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc51c09; wu:fc51c09
    Summary
    Predicted to enable RNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome and positive regulation of transcription by RNA polymerase II. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 54. Orthologous to human HNRNPU (heterogeneous nuclear ribonucleoprotein U). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hnrnpua in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (11472510..11495438, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (11317812..11341382, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit alpha 3 Neighboring gene ADP-dependent glucokinase 2 Neighboring gene EF-hand calcium binding domain 2 Neighboring gene kinesin family member 26Ba Neighboring gene golgin subfamily A member 6-like protein 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phenotypic analysis of catastrophic childhood epilepsy genes. Griffin A, et al. Commun Biol, 2021 Jun 3. PMID 34083748, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables promoter-specific chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein U; heterogeneous nuclear ribonucleoprotein Ua

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      11472510..11495438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158649.5 → XP_005158706.1  heterogeneous nuclear ribonucleoprotein U isoform X2

      UniProtKB/TrEMBL
      A0A8M2B529
      Conserved Domains (4) summary
      smart00513
      Location:6 → 40
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam13671
      Location:408 → 552
      AAA_33; AAA domain
      cd12884
      Location:197 → 372
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:408 → 562
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    2. XM_689599.10 → XP_694691.5  heterogeneous nuclear ribonucleoprotein U isoform X1

      UniProtKB/TrEMBL
      A0A8N7UR79, E7F3J2
      Related
      ENSDARP00000020535.6, ENSDART00000020598.8
      Conserved Domains (4) summary
      smart00513
      Location:6 → 40
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam13671
      Location:408 → 552
      AAA_33; AAA domain
      cd12884
      Location:197 → 372
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:408 → 562
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    Nucleotide Protein
    Heading Accession and Version

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