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    sh3pxd2b SH3 and PX domains 2B [ Danio rerio (zebrafish) ]

    Gene ID: 553242, updated on 4-Jan-2025

    Summary

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    Official Symbol
    sh3pxd2bprovided by ZNC
    Official Full Name
    SH3 and PX domains 2Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060810-52
    See related
    Ensembl:ENSDARG00000103251 AllianceGenome:ZFIN:ZDB-GENE-060810-52
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7155315; wu:fb09f08
    Summary
    Predicted to enable superoxide-generating NADPH oxidase activator activity. Acts upstream of or within bone morphogenesis and connective tissue development. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; notochord; otic vesicle; segmental plate; and tail bud. Used to study Frank-Ter Haar syndrome. Human ortholog(s) of this gene implicated in Frank-Ter Haar syndrome. Orthologous to human SH3PXD2B (SH3 and PX domains 2B). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See sh3pxd2b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (42717406..42780082)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (42722117..42784791)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488871 Neighboring gene uncharacterized LOC103909490 Neighboring gene uncharacterized LOC137488872 Neighboring gene serine/threonine kinase 10 Neighboring gene zmp:0000001268

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The novel zebrafish model pretzel demonstrates a central role for SH3PXD2B in defective collagen remodelling and fibrosis in Frank-Ter Haar syndrome. de Vos IJHM, et al. Biol Open, 2020 Dec 29. PMID 33234702, Free PMC Article
    2. Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes. Kawahara T, et al. BMC Evol Biol, 2007 Sep 27. PMID 17900370, Free PMC Article
    3. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables superoxide-generating NADPH oxidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables superoxide-generating NADPH oxidase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within connective tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in superoxide anion generation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SH3 and PX domain-containing protein 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      42717406..42780082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170288.4 → XP_005170345.1  SH3 and PX domain-containing protein 2B isoform X1

      See identical proteins and their annotated locations for XP_005170345.1

      UniProtKB/TrEMBL
      A0A0R4IMX7, A0A8M2BHM1
      Related
      ENSDARP00000137221.1, ENSDART00000166936.2
      Conserved Domains (5) summary
      cd06888
      Location:6 → 124
      PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
      cd12018
      Location:823 → 878
      SH3_Tks4_4; Fourth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
      cd12075
      Location:166 → 220
      SH3_Tks4_1; First Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
      cd12076
      Location:234 → 287
      SH3_Tks4_2; Second Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
      cd12078
      Location:371 → 423
      SH3_Tks4_3; Third Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains

    2. XM_021469251.2 → XP_021324926.1  SH3 and PX domain-containing protein 2B isoform X2

      UniProtKB/TrEMBL
      A0A8M9PRL0
      Conserved Domains (7) summary
      cd06888
      Location:6 → 124
      PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
      cd12018
      Location:822 → 877
      SH3_Tks4_4; Fourth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
      cd12075
      Location:166 → 220
      SH3_Tks4_1; First Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
      cd12076
      Location:234 → 287
      SH3_Tks4_2; Second Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
      cd12078
      Location:370 → 422
      SH3_Tks4_3; Third Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
      TIGR04211
      Location:252 → 325
      SH3_and_anchor; SH3 domain protein
      cl25526
      Location:605 → 680
      TonB_N; TonB N-terminal region

    3. XM_003200907.5 → XP_003200955.2  SH3 and PX domain-containing protein 2B isoform X3

      UniProtKB/TrEMBL
      A0A0R4IRP5, A0A8M1RMY5
      Related
      ENSDARP00000139646.1, ENSDART00000172135.2
      Conserved Domains (5) summary
      cd06888
      Location:6 → 124
      PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
      cd12018
      Location:811 → 866
      SH3_Tks4_4; Fourth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
      cd12075
      Location:154 → 208
      SH3_Tks4_1; First Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
      cd12076
      Location:222 → 275
      SH3_Tks4_2; Second Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
      cd12078
      Location:359 → 411
      SH3_Tks4_3; Third Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    Nucleotide Protein Strain
    Heading Accession and Version

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