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    mcm3ap minichromosome maintenance complex component 3 associated protein [ Danio rerio (zebrafish) ]

    Gene ID: 436589, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mcm3approvided by ZNC
    Official Full Name
    minichromosome maintenance complex component 3 associated proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040715-1
    See related
    Ensembl:ENSDARG00000021402 AllianceGenome:ZFIN:ZDB-GENE-040715-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be part of transcription export complex 2. Predicted to be active in cytoplasm and nucleus. Orthologous to human MCM3AP (minichromosome maintenance complex component 3 associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mcm3ap in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (38457873..38481479)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (38647918..38671684)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene zgc:136333 Neighboring gene cytochrome P450, family 27, subfamily A, polypeptide 1, gene 4 Neighboring gene lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) Neighboring gene leishmanolysin-like (metallopeptidase M8 family)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (HDAC) and lysine acetyltransferase (KAT) genes. Fellous A, et al. Gene, 2019 Apr 5. PMID 30615915
    2. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
    3. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription export complex 2 IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    80 kDa MCM3-associated protein; germinal-center associated nuclear protein
    Names
    MCM3 minichromosome maintenance deficient 3 associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      38457873..38481479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167868.5 → XP_005167925.1  germinal-center associated nuclear protein

      UniProtKB/TrEMBL
      A0A8M2BFC0, F1Q712
      Related
      ENSDARP00000121220.1, ENSDART00000142512.2
      Conserved Domains (6) summary
      cd12443
      Location:481 → 553
      RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
      pfam03399
      Location:738 → 962
      SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
      pfam13634
      Location:3 → 81
      Nucleoporin_FG; Nucleoporin FG repeat region
      pfam16766
      Location:1226 → 1294
      CID_GANP; Binding region of GANP to ENY2
      pfam16768
      Location:2 → 310
      NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
      pfam16769
      Location:1324 → 2114
      MCM3AP_GANP; MCM3AP domain of GANP

    2. XM_068223663.1 → XP_068079764.1  germinal-center associated nuclear protein

      UniProtKB/TrEMBL
      A0A8M2BFC0, F1Q712
      Related
      ENSDARP00000019686.7, ENSDART00000008053.9
    Nucleotide Protein Strain
    Heading Accession and Version

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