hoxd12a homeobox D12a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hoxd12aprovided by ZNC
Official Full Name: homeobox D12aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-118
See related: Ensembl:ENSDARG00000059263 AllianceGenome:ZFIN:ZDB-GENE-990415-118
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hoxd12; HOX-D12; hoxd-12
Summary: Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including fin; mesenchyme; pectoral fin bud; pectoral fin field; and tail bud. Human ortholog(s) of this gene implicated in clubfoot. Orthologous to human HOXD12 (homeobox D12). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (1981822..1984606, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (1981085..1983827, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein Hox-D12a

Names: homeo box D12a; homeobox gene D-12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126486.1 → NP_001119958.1 homeobox protein Hox-D12a

Status: PROVISIONAL

Source sequence(s)

BX322661

UniProtKB/TrEMBL

A0A8M1NJM5, B0S5Y9

Related

ENSDARP00000076775.6, ENSDART00000082339.6

Conserved Domains (1) summary

pfam00046
Location:212 → 265

Homeobox; Homeobox domain