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    uba1 ubiquitin-like modifier activating enzyme 1 [ Danio rerio (zebrafish) ]

    Gene ID: 406335, updated on 4-Jan-2025

    Summary

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    Official Symbol
    uba1provided by ZNC
    Official Full Name
    ubiquitin-like modifier activating enzyme 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2009
    See related
    Ensembl:ENSDARG00000037559 AllianceGenome:ZFIN:ZDB-GENE-040426-2009
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ube1; fb30f01; zgc:66143; wu:fa01e08; wu:fb30f01; wu:fi21c11; wu:fj14g11
    Summary
    Predicted to enable ubiquitin activating enzyme activity. Acts upstream of or within axonogenesis and regulation of inflammatory response. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Orthologous to human UBA1 (ubiquitin like modifier activating enzyme 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See uba1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (20640509..20664537)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (20714146..20738278)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene skin secretory protein xP2-like Neighboring gene CaM kinase-like vesicle-associated, like Neighboring gene Rho guanine nucleotide exchange factor (GEF) 3, like Neighboring gene ubiquitin specific peptidase 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy. Wishart TM, et al. J Clin Invest, 2014 Apr. PMID 24590288, Free PMC Article
    2. Zebrafish Uba1 Degrades IRF3 through K48-Linked Ubiquitination to Inhibit IFN Production. Chen DD, et al. J Immunol, 2021 Jul 15. PMID 34193603
    3. Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease. Beck DB, et al. N Engl J Med, 2020 Dec 31. PMID 33108101, Free PMC Article
    4. Insights into the evolution of the ISG15 and UBA7 system. Liu S, et al. Genomics, 2022 Mar. PMID 35134494
    5. Transcriptome kinetics of arsenic-induced adaptive response in zebrafish liver. Lam SH, et al. Physiol Genomics, 2006 Nov 27. PMID 16882884

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-like modifier-activating enzyme 1
    Names
    ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing)
    NP_998227.1
    XP_005162108.1
    XP_005162109.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213062.1 → NP_998227.1  ubiquitin-like modifier-activating enzyme 1

      See identical proteins and their annotated locations for NP_998227.1

      Status: PROVISIONAL

      Source sequence(s)
      BC060674
      UniProtKB/TrEMBL
      Q6P9P3
      Related
      ENSDARP00000054690.4, ENSDART00000054691.6
      Conserved Domains (4) summary
      cd01490
      Location:471 → 1011
      Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      cd01491
      Location:54 → 436
      Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      TIGR01408
      Location:49 → 1055
      Ube1; ubiquitin-activating enzyme E1
      pfam16191
      Location:303 → 366
      E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      20640509..20664537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162052.5 → XP_005162109.1  ubiquitin-like modifier-activating enzyme 1 isoform X1

      See identical proteins and their annotated locations for XP_005162109.1

      UniProtKB/TrEMBL
      A0A8M2B975, F1RCA1
      Conserved Domains (4) summary
      cd01490
      Location:471 → 1011
      Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      cd01491
      Location:54 → 436
      Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      TIGR01408
      Location:49 → 1055
      Ube1; ubiquitin-activating enzyme E1
      pfam16191
      Location:303 → 366
      E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle

    2. XM_005162051.5 → XP_005162108.1  ubiquitin-like modifier-activating enzyme 1 isoform X1

      See identical proteins and their annotated locations for XP_005162108.1

      UniProtKB/TrEMBL
      A0A8M2B975, F1RCA1
      Conserved Domains (4) summary
      cd01490
      Location:471 → 1011
      Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      cd01491
      Location:54 → 436
      Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      TIGR01408
      Location:49 → 1055
      Ube1; ubiquitin-activating enzyme E1
      pfam16191
      Location:303 → 366
      E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle
    Nucleotide Protein Strain
    Heading Accession and Version

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