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    ehmt1b euchromatic histone-lysine N-methyltransferase 1b [ Danio rerio (zebrafish) ]

    Gene ID: 402830, updated on 4-Jan-2025

    Summary

    Official Symbol
    ehmt1bprovided by ZNC
    Official Full Name
    euchromatic histone-lysine N-methyltransferase 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080515-3
    See related
    Ensembl:ENSDARG00000026634 AllianceGenome:ZFIN:ZDB-GENE-080515-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable p53 binding activity; protein methyltransferase activity; and zinc ion binding activity. Predicted to be located in chromosome and nucleus. Human ortholog(s) of this gene implicated in Kleefstra syndrome and Kleefstra syndrome 1. Orthologous to human EHMT1 (euchromatic histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    NEW
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    Genomic context

    See ehmt1b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (14644247..14692123, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (14547493..14595412, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene si:ch211-196i2.1 Neighboring gene calcium channel, voltage-dependent, N type, alpha 1B subunit, b Neighboring gene GTPase IMAP family member 4 Neighboring gene arrestin domain containing 1b Neighboring gene glutamine synthetase-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-lysine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase EHMT1
    Names
    euchromatic histone methyltransferase 1b
    NP_001166035.1
    XP_005161162.1
    XP_009293515.1
    XP_009293516.1
    XP_009293517.1
    XP_009293518.1
    XP_021324462.1
    XP_021324463.1
    XP_021324464.1
    XP_021324465.1
    XP_021324466.1
    XP_068071922.1
    XP_068071923.1
    XP_068071924.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172564.1NP_001166035.1  histone-lysine N-methyltransferase EHMT1

      Status: VALIDATED

      Source sequence(s)
      CR936260
      UniProtKB/TrEMBL
      A0A8M1NVV8
      Related
      ENSDARP00000111271.2, ENSDART00000123047.3
      Conserved Domains (7) summary
      smart00248
      Location:752781
      ANK; ankyrin repeats
      smart00317
      Location:11061227
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:780906
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00023
      Location:918950
      Ank; Ankyrin repeat
      pfam05033
      Location:9931097
      Pre-SET; Pre-SET motif
      pfam12796
      Location:790883
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:785816
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      14644247..14692123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215822.1XP_068071923.1  histone-lysine N-methyltransferase EHMT1 isoform X9

    2. XM_009295241.3XP_009293516.1  histone-lysine N-methyltransferase EHMT1 isoform X4

      UniProtKB/TrEMBL
      A0A8M3AM13
      Conserved Domains (7) summary
      smart00248
      Location:760789
      ANK; ankyrin repeats
      smart00317
      Location:11141235
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:788914
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00023
      Location:926958
      Ank; Ankyrin repeat
      pfam05033
      Location:10011105
      Pre-SET; Pre-SET motif
      pfam12796
      Location:798891
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:793824
      ANK; ANK repeat [structural motif]
    3. XM_068215823.1XP_068071924.1  histone-lysine N-methyltransferase EHMT1 isoform X10

      UniProtKB/TrEMBL
      A0A8M3AWQ8
    4. XM_005161105.5XP_005161162.1  histone-lysine N-methyltransferase EHMT1 isoform X6

      UniProtKB/TrEMBL
      A0A8M2B810
      Conserved Domains (7) summary
      smart00248
      Location:754783
      ANK; ankyrin repeats
      smart00317
      Location:11081229
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:782908
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00023
      Location:920952
      Ank; Ankyrin repeat
      pfam05033
      Location:9951099
      Pre-SET; Pre-SET motif
      pfam12796
      Location:792885
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:787818
      ANK; ANK repeat [structural motif]
    5. XM_009295240.4XP_009293515.1  histone-lysine N-methyltransferase EHMT1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B4K4
      Conserved Domains (7) summary
      smart00248
      Location:762791
      ANK; ankyrin repeats
      smart00317
      Location:11161237
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:790916
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00023
      Location:928960
      Ank; Ankyrin repeat
      pfam05033
      Location:10031107
      Pre-SET; Pre-SET motif
      pfam12796
      Location:800893
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:795826
      ANK; ANK repeat [structural motif]
    6. XM_068215821.1XP_068071922.1  histone-lysine N-methyltransferase EHMT1 isoform X8

    7. XM_021468790.2XP_021324465.1  histone-lysine N-methyltransferase EHMT1 isoform X7

      UniProtKB/TrEMBL
      A0A8M9PTR6
      Conserved Domains (5) summary
      smart00317
      Location:11061227
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:780906
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:785816
      ANK; ANK repeat [structural motif]
      pfam05033
      Location:9931097
      Pre-SET; Pre-SET motif
      pfam12796
      Location:722816
      Ank_2; Ankyrin repeats (3 copies)
    8. XM_021468788.2XP_021324463.1  histone-lysine N-methyltransferase EHMT1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PCJ6
      Conserved Domains (6) summary
      smart00317
      Location:11151236
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:789915
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:794825
      ANK; ANK repeat [structural motif]
      pfam05033
      Location:10021106
      Pre-SET; Pre-SET motif
      pfam05104
      Location:169320
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
      pfam12796
      Location:731825
      Ank_2; Ankyrin repeats (3 copies)
    9. XM_021468791.2XP_021324466.1  histone-lysine N-methyltransferase EHMT1 isoform X11

      UniProtKB/TrEMBL
      A0A8M9PQC0
      Conserved Domains (6) summary
      smart00317
      Location:10751196
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:749875
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:754785
      ANK; ANK repeat [structural motif]
      pfam05033
      Location:9621066
      Pre-SET; Pre-SET motif
      pfam12796
      Location:691785
      Ank_2; Ankyrin repeats (3 copies)
      cl26464
      Location:27278
      Atrophin-1; Atrophin-1 family
    10. XM_021468787.2XP_021324462.1  histone-lysine N-methyltransferase EHMT1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9P384
      Conserved Domains (6) summary
      smart00317
      Location:11231244
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:797923
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:802833
      ANK; ANK repeat [structural motif]
      pfam05033
      Location:10101114
      Pre-SET; Pre-SET motif
      pfam12796
      Location:739833
      Ank_2; Ankyrin repeats (3 copies)
      cl26464
      Location:27278
      Atrophin-1; Atrophin-1 family
    11. XM_009295243.4XP_009293518.1  histone-lysine N-methyltransferase EHMT1 isoform X10

      See identical proteins and their annotated locations for XP_009293518.1

      UniProtKB/TrEMBL
      A0A8M3AWQ8
      Conserved Domains (7) summary
      smart00248
      Location:739768
      ANK; ankyrin repeats
      smart00317
      Location:10931214
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:767893
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00023
      Location:905937
      Ank; Ankyrin repeat
      pfam05033
      Location:9801084
      Pre-SET; Pre-SET motif
      pfam12796
      Location:777870
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:772803
      ANK; ANK repeat [structural motif]
    12. XM_021468789.2XP_021324464.1  histone-lysine N-methyltransferase EHMT1 isoform X5

      UniProtKB/TrEMBL
      A0A8M9PI65
      Conserved Domains (6) summary
      smart00317
      Location:11131234
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:787913
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:792823
      ANK; ANK repeat [structural motif]
      pfam05033
      Location:10001104
      Pre-SET; Pre-SET motif
      pfam12796
      Location:729823
      Ank_2; Ankyrin repeats (3 copies)
      cl26464
      Location:17268
      Atrophin-1; Atrophin-1 family
    13. XM_009295242.4XP_009293517.1  histone-lysine N-methyltransferase EHMT1 isoform X10

      See identical proteins and their annotated locations for XP_009293517.1

      UniProtKB/TrEMBL
      A0A8M3AWQ8
      Conserved Domains (7) summary
      smart00248
      Location:739768
      ANK; ankyrin repeats
      smart00317
      Location:10931214
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:767893
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00023
      Location:905937
      Ank; Ankyrin repeat
      pfam05033
      Location:9801084
      Pre-SET; Pre-SET motif
      pfam12796
      Location:777870
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:772803
      ANK; ANK repeat [structural motif]

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395080.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      274163..320903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)