kita KIT proto-oncogene, receptor tyrosine kinase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kitaprovided by ZNC
Official Full Name: KIT proto-oncogene, receptor tyrosine kinase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-464
See related: Ensembl:ENSDARG00000043317 AllianceGenome:ZFIN:ZDB-GENE-980526-464
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: kit; c-kit; sparse; receptor
Summary: Predicted to enable growth factor binding activity and transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within several processes, including melanocyte apoptotic process; melanocyte differentiation; and stem cell fate commitment. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including digestive system; gonad; mesoderm; nervous system; and neural crest. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal stromal tumor; germ cell cancer (multiple); mastocytosis; piebaldism; and renal cell carcinoma. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (22331148..22378422, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (22434805..22478783, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of c-kit and beta-catenin suggests that erythropoietin may exert a role in regeneration reducing the extent of tubular damage from the outset after gentamicin administration.
Title: Renoprotective effect of erythropoietin in zebrafish after administration of gentamicin: an immunohistochemical study for β-catenin and c-kit expression.
strong evidence for a Kit-mediated bi-directional communication system in the zebrafish ovarian follicle
Title: Spatial distribution and receptor specificity of zebrafish Kit system--evidence for a Kit-mediated bi-directional communication system in the preovulatory ovarian follicle.
The regeneration defect in kita mutants is not due to defects in melanocyte stem cells recruitment or in the proliferation, differentiation or survival of the daughter cells, but is instead due to a defect in stem cell establishment.
Title: Kit signaling is involved in melanocyte stem cell fate decisions in zebrafish embryos.
The role of ErbB and Kit signalling in establishing melanophore stem cells in zebrafish.
Title: On the embryonic origin of adult melanophores: the role of ErbB and Kit signalling in establishing melanophore stem cells in zebrafish.
Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish
Title: Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish.
Ectopic expression of foxd3 indicates that foxd3 promotes early melanophore death only when kit is inactive
Title: Kit and foxd3 genetically interact to regulate melanophore survival in zebrafish.
melanocyte changes its response to Kit receptor signaling and function during development, first to promote migration, then to promote survival through distinct Kit-dependent mechanisms.
Title: Temporal and molecular separation of the kit receptor tyrosine kinase's roles in zebrafish melanocyte migration and survival.
kit is required for melanocyte differentiation in zebrafish when melanoblast development is delayed.
Title: A requirement for kit in embryonic zebrafish melanocyte differentiation is revealed by melanoblast delay.

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General gene information

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Markers

kit (e-PCR), detects polymorphism
- UniSTS:205584

z49730 (e-PCR), detects polymorphism
- UniSTS:238468

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cytokine binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Fc receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Fc receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Kit signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Kit signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within developmental pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gastro-intestinal system smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic progenitor cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within melanocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of melanocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanocyte migration	IMP Inferred from Mutant Phenotype more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stem cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mast/stem cell growth factor receptor kita

Names: SCFR; c-kit homolog; kit receptor a; proto-oncogene tyrosine-protein kinase Kit; spa; spa-1; tyrosine kinase; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a

NP_571128.1

EC 2.7.10.1

XP_009292909.1

EC 2.7.10.1

XP_009292910.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131053.1 → NP_571128.1 mast/stem cell growth factor receptor kita precursor

See identical proteins and their annotated locations for NP_571128.1

Status: PROVISIONAL

Source sequence(s)

AF153446

UniProtKB/Swiss-Prot

Q5RID5, Q8JFR5, Q9W755

Related

ENSDARP00000024170.7, ENSDART00000011135.8

Conserved Domains (5) summary

smart00410
Location:213 → 302

IG_like; Immunoglobulin like

cd05104
Location:544 → 913

PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit

pfam00047
Location:213 → 292

ig; Immunoglobulin domain

pfam07714
Location:580 → 909

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:306 → 405

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

22331148..22378422 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009294634.4 → XP_009292909.1 mast/stem cell growth factor receptor kita isoform X2

UniProtKB/Swiss-Prot

Q5RID5, Q8JFR5, Q9W755

UniProtKB/TrEMBL

A0A8M3ALF9

Conserved Domains (5) summary

smart00410
Location:214 → 303

IG_like; Immunoglobulin like

cd05104
Location:545 → 914

PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit

pfam00047
Location:214 → 293

ig; Immunoglobulin domain

pfam07714
Location:581 → 910

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:307 → 406

Ig; Immunoglobulin domain
XM_009294635.4 → XP_009292910.1 mast/stem cell growth factor receptor kita isoform X1

See identical proteins and their annotated locations for XP_009292910.1

UniProtKB/Swiss-Prot

Q5RID5, Q8JFR5, Q9W755

UniProtKB/TrEMBL

A0A8M3AW51, B3DGS5, E7FFW1

Related

ENSDARP00000099069.3, ENSDART00000110967.4

Conserved Domains (5) summary

smart00410
Location:218 → 307

IG_like; Immunoglobulin like

cd05104
Location:549 → 918

PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit

pfam00047
Location:218 → 297

ig; Immunoglobulin domain

pfam07714
Location:585 → 914

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:311 → 410

Ig; Immunoglobulin domain