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    ttc7a tetratricopeptide repeat domain 7A [ Danio rerio (zebrafish) ]

    Gene ID: 559345, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ttc7aprovided by ZNC
    Official Full Name
    tetratricopeptide repeat domain 7Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010319-27
    See related
    Ensembl:ENSDARG00000074760 AllianceGenome:ZFIN:ZDB-GENE-010319-27
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    id:ibd5135; si:ch211-93n23.6
    Summary
    Acts upstream of or within digestive tract development. Is expressed in brain; ectoderm; intestine; and notochord. Human ortholog(s) of this gene implicated in multiple intestinal atresia. Orthologous to human TTC7A (tetratricopeptide repeat domain 7A). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See ttc7a in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (8696776..8756053)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (8361353..8424043)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene PROP paired-like homeobox 1 Neighboring gene multiple coagulation factor deficiency 2, ER cargo receptor complex subunit Neighboring gene si:ch211-93n23.7 Neighboring gene calmodulin 2a (phosphorylase kinase, delta)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency. Jardine S, et al. Gastroenterology, 2020 Mar. PMID 31743734, Free PMC Article
    2. Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish. Zhao S, et al. Nat Commun, 2018 Jul 6. PMID 29980668, Free PMC Article
    3. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 7A; LOW QUALITY PROTEIN: tetratricopeptide repeat protein 7A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      8696776..8756053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480723.2 → XP_021336398.1  tetratricopeptide repeat protein 7A isoform X1

      UniProtKB/TrEMBL
      A0A8M1QQW3, A0A8M9QA29, F1Q5B2
      Related
      ENSDARP00000099007.3, ENSDART00000109059.4
      Conserved Domains (4) summary
      sd00008
      Location:437 → 464
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:703 → 730
      TPR; TPR repeat [structural motif]
      cl26002
      Location:706 → 798
      TPR_11; TPR repeat
      cl26860
      Location:400 → 446
      PRK15359; type III secretion system chaperone protein SscB; Provisional

    2. XM_021480722.2 → XP_021336397.2  tetratricopeptide repeat protein 7A isoform X2

      UniProtKB/TrEMBL
      A0A8M9PYB7

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394864.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      369439..428716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009307117.4 → XP_009305392.1  tetratricopeptide repeat protein 7A isoform X1

      UniProtKB/TrEMBL
      A0A8M1QQW3, A0A8M9QA29, F1Q5B2
      Conserved Domains (4) summary
      sd00008
      Location:437 → 464
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:703 → 730
      TPR; TPR repeat [structural motif]
      cl26002
      Location:706 → 798
      TPR_11; TPR repeat
      cl26860
      Location:400 → 446
      PRK15359; type III secretion system chaperone protein SscB; Provisional

    2. XM_009307116.4 → XP_009305391.2  tetratricopeptide repeat protein 7A isoform X2

      UniProtKB/TrEMBL
      A0A8M9PYB7

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395306.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      104442..166257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474272.2 → XP_021329947.2  LOW QUALITY PROTEIN: tetratricopeptide repeat protein 7A isoform X1

      UniProtKB/TrEMBL
      A0A8M9PFH5
    Nucleotide Protein
    Heading Accession and Version

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