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    agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 [ Danio rerio (zebrafish) ]

    Gene ID: 324332, updated on 4-Jan-2025

    Summary

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    Official Symbol
    agap3provided by ZNC
    Official Full Name
    ArfGAP with GTPase domain, ankyrin repeat and PH domain 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-110927-1
    See related
    Ensembl:ENSDARG00000087822 AllianceGenome:ZFIN:ZDB-GENE-110927-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc25h09; fj34h05; wu:fc25h09; wu:fj34h05
    Summary
    Predicted to enable several functions, including GTP binding activity; GTPase activator activity; and GTPase activity. Orthologous to human AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See agap3 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (34138482..34949444, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (34251180..35063564, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438358 Neighboring gene ankyrin repeat and SOCS box containing 10 Neighboring gene gastrulation brain homeobox 1 Neighboring gene catenin (cadherin-associated protein), alpha 1 Neighboring gene leucine rich repeat transmembrane neuronal 2 Neighboring gene melanin concentrating hormone receptor 2b Neighboring gene RB1-inducible coiled-coil 1 Neighboring gene ST18 C2H2C-type zinc finger transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0167

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      34138482..34949444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353885.3 → XP_017209374.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M6YWA1

    2. XM_009297586.4 → XP_009295861.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AW63
      Conserved Domains (8) summary
      cd04103
      Location:52 → 209
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      smart00010
      Location:50 → 215
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd00204
      Location:742 → 802
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01250
      Location:321 → 568
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      pfam00169
      Location:324 → 388
      PH; PH domain
      pfam01412
      Location:587 → 698
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:733 → 802
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:744 → 775
      ANK; ANK repeat [structural motif]

    3. XM_009297585.4 → XP_009295860.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AZA0
      Related
      ENSDARP00000106871.2, ENSDART00000128690.3
      Conserved Domains (8) summary
      cd04103
      Location:509 → 666
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      smart00010
      Location:507 → 672
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd00204
      Location:1199 → 1259
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01250
      Location:778 → 1025
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      pfam00169
      Location:781 → 845
      PH; PH domain
      pfam01412
      Location:1044 → 1155
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:1190 → 1259
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:1201 → 1232
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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