U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    traf2b Tnf receptor-associated factor 2b [ Danio rerio (zebrafish) ]

    Gene ID: 557526, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    traf2bprovided by ZNC
    Official Full Name
    Tnf receptor-associated factor 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5345
    See related
    Ensembl:ENSDARG00000101036 AllianceGenome:ZFIN:ZDB-GENE-030131-5345
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fd14c07; wu:fd14c07; si:dkey-170o10.1
    Summary
    Predicted to enable signaling adaptor activity; tumor necrosis factor receptor binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction and tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within several processes, including activation of NF-kappaB-inducing kinase activity; protein autoubiquitination; and regulation of JNK cascade. Predicted to be active in cytoplasm. Orthologous to human TRAF2 (TNF receptor associated factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See traf2b in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (54422906..54454200)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (53778024..53807932)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene zinc finger, MYND-type containing 19 Neighboring gene B-box and SPRY domain containing Neighboring gene coenzyme Q4 homolog (S. cerevisiae) Neighboring gene F-box and WD repeat domain containing 5 Neighboring gene uncharacterized LOC101882650

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. CRISPR/Cas9-mediated knockout of tnf-α1 in zebrafish reduces disease resistance after Edwardsiella piscicida bacterial infection. Nadarajapillai K, et al. Fish Shellfish Immunol, 2024 Jan. PMID 38040136
    2. Myocardial NF-κB activation is essential for zebrafish heart regeneration. Karra R, et al. Proc Natl Acad Sci U S A, 2015 Oct 27. PMID 26472034, Free PMC Article
    3. The viral TRAF protein (ORF111L) from infectious spleen and kidney necrosis virus interacts with TRADD and induces caspase 8-mediated apoptosis. He BL, et al. PLoS One, 2012. PMID 22615868, Free PMC Article
    4. Silica nanoparticles trigger hepatic lipid-metabolism disorder in vivo and in vitro. Duan J, et al. Int J Nanomedicine, 2018. PMID 30519016, Free PMC Article
    5. Edwardsiella tarda-Induced Inhibition of Apoptosis: A Strategy for Intracellular Survival. Zhou ZJ, et al. Front Cell Infect Microbiol, 2016. PMID 27471679, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tumor necrosis factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within activation of NF-kappaB-inducing kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein autoubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tumor necrosis factor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of plasma membrane signaling receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    TNF receptor-associated factor 2
    Names
    tumor necrosis factor receptor associate factor-2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      54422906..54454200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068221528.1 → XP_068077629.1  TNF receptor-associated factor 2 isoform X1

      Related
      ENSDARP00000144196.1, ENSDART00000175157.2

    2. XM_678539.10 → XP_683631.2  TNF receptor-associated factor 2 isoform X2

      See identical proteins and their annotated locations for XP_683631.2

      UniProtKB/TrEMBL
      A0A0R4ILY5, A0A8M2BD02
      Related
      ENSDARP00000140601.1, ENSDART00000169531.2
      Conserved Domains (4) summary
      cd00162
      Location:44 → 86
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03778
      Location:365 → 528
      MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:189 → 246
      zf-TRAF; TRAF-type zinc finger
      pfam16673
      Location:307 → 359
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    3. XM_005165500.5 → XP_005165557.1  TNF receptor-associated factor 2 isoform X2

      See identical proteins and their annotated locations for XP_005165557.1

      UniProtKB/TrEMBL
      A0A0R4ILY5, A0A8M2BD02
      Related
      ENSDARP00000137113.1, ENSDART00000165672.2
      Conserved Domains (4) summary
      cd00162
      Location:44 → 86
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03778
      Location:365 → 528
      MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:189 → 246
      zf-TRAF; TRAF-type zinc finger
      pfam16673
      Location:307 → 359
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    4. XM_005165499.5 → XP_005165556.1  TNF receptor-associated factor 2 isoform X2

      See identical proteins and their annotated locations for XP_005165556.1

      UniProtKB/TrEMBL
      A0A0R4ILY5, A0A8M2BD02
      Conserved Domains (4) summary
      cd00162
      Location:44 → 86
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03778
      Location:365 → 528
      MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:189 → 246
      zf-TRAF; TRAF-type zinc finger
      pfam16673
      Location:307 → 359
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.