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    ITPK4 inositol 1,3,4-trisphosphate 5/6-kinase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819003, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ITPK4
    Official Full Name
    inositol 1,3,4-trisphosphate 5/6-kinase 4
    Primary source
    TAIR:AT2G43980
    Locus tag
    AT2G43980
    See related
    Araport:AT2G43980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''inositol 1; 3; 4-trisphosphate 5/6-kinase 4; 4-trisphosphate 5/6-kinase 4''; AtITPK4; F6E13.11; inositol 1
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    Genomic context

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    See ITPK4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Sequence:
    Chromosome: 2; NC_003071.7 (18208253..18211644, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene SWAP (Suppressor-of-White-APricot)/surp domain-containing protein Neighboring gene RNA-binding protein Neighboring gene GPI-anchored adhesin-like protein Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlier AtITPK4. Whitfield HL, et al. Biochem J, 2023 Mar 29. PMID 36896917, Free PMC Article
    2. Simultaneous mutations in ITPK4 and MRP5 genes result in a low phytic acid level without compromising salt tolerance in Arabidopsis. Ren Y, et al. J Integr Plant Biol, 2024 Oct. PMID 39031490
    3. Arabidopsis thaliana inositol 1,3,4-trisphosphate 5/6-kinase 4 (AtITPK4) is an outlier to a family of ATP-grasp fold proteins from Arabidopsis. Sweetman D, et al. FEBS Lett, 2007 Sep 4. PMID 17698066
    4. Identification of genes necessary for wild-type levels of seed phytic acid in Arabidopsis thaliana using a reverse genetics approach. Kim SI, et al. Mol Genet Genomics, 2011 Aug. PMID 21698461
    5. MAPK target networks in Arabidopsis thaliana revealed using functional protein microarrays. Popescu SC, et al. Genes Dev, 2009 Jan 1. PMID 19095804, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Simultaneous mutations in ITPK4 and MRP5 genes result in a low phytic acid level without compromising salt tolerance in Arabidopsis.
      Title: Simultaneous mutations in ITPK4 and MRP5 genes result in a low phytic acid level without compromising salt tolerance in Arabidopsis.
    2. Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlier AtITPK4.
      Title: Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlier AtITPK4.
    3. AtITPK4 differs from other family members in that it does not display inositol 3,4,5,6-tetrakisphosphate 1-kinase activity; rather, it displays inositol 1,4,5,6-tetrakisphosphate and inositol 1,3,4,5-tetrakisphosphate isomerase activity.
      Title: Arabidopsis thaliana inositol 1,3,4-trisphosphate 5/6-kinase 4 (AtITPK4) is an outlier to a family of ATP-grasp fold proteins from Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_180076.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inositol-1,3,4-trisphosphate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-1,3,4-trisphosphate 6-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-3,4,5,6-tetrakisphosphate 1-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol trisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within myo-inositol hexakisphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    inositol 1,3,4-trisphosphate 5/6-kinase 4
    NP_850407.1
    • ''inositol 1,3,4-trisphosphate 5/6-kinase 4'' (ITPK4); FUNCTIONS IN: magnesium ion binding, inositol-1,3,4-trisphosphate 5/6-kinase activity, catalytic activity, ATP binding, inositol tetrakisphosphate 1-kinase activity; INVOLVED IN: inositol trisphosphate metabolic process; LOCATED IN: intracellular; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Inositol-tetrakisphosphate 1-kinase, uncharacterised-N-terminal (InterPro:IPR017418), Inositol 1, 3, 4-trisphosphate 56-kinase (InterPro:IPR008656); BEST Arabidopsis thaliana protein match is: Inositol 1,3,4-trisphosphate 5/6-kinase family protein (TAIR:AT4G08170.2); Has 388 Blast hits to 384 proteins in 77 species: Archae - 0; Bacteria - 0; Metazoa - 95; Fungi - 0; Plants - 245; Viruses - 0; Other Eukaryotes - 48 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18208253..18211644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180076.2 → NP_850407.1  inositol 1,3,4-trisphosphate 5/6-kinase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850407.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80568, Q8VYL6
      UniProtKB/TrEMBL
      A0A178VX11, A0A5S9X6T1
      Conserved Domains (1) summary
      cl17255
      Location:295 → 464
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80568.2

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