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    AUX1 Transmembrane amino acid transporter family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818390, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AUX1
    Official Full Name
    Transmembrane amino acid transporter family protein
    Primary source
    TAIR:AT2G38120
    Locus tag
    AT2G38120
    See related
    Araport:AT2G38120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtAUX1; AUXIN RESISTANT 1; F16M14.5; F16M14_5; MAP1; MODIFIER OF ARF7/NPH4 PHENOTYPES 1; PIR1; WAV5; WAVY ROOTS 5
    Summary
    Encodes an auxin influx transporter. AUX1 resides at the apical plasma membrane of protophloem cells and at highly dynamic subpopulations of Golgi apparatus and endosomes in all cell types. AUX1 action in the lateral root cap and/or epidermal cells influences lateral root initiation and positioning. Shoot supplied ammonium targets AUX1 and inhibits lateral root emergence.
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    Genomic context

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    See AUX1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (15972876..15977180)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene glycerol-3-phosphate acyltransferase 6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Acyl-CoA N-acyltransferases (NAT) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis aux1rcr1 mutation alters AUXIN RESISTANT1 targeting and prevents expression of the auxin reporter DR5:GUS in the root apex. Yu J, et al. J Exp Bot, 2013 Feb. PMID 23293348, Free PMC Article
    2. Arabidopsis AUX1 gene: a permease-like regulator of root gravitropism. Bennett MJ, et al. Science, 1996 Aug 16. PMID 8688077
    3. The Arabidopsis AUX1 gene: a model system to study mRNA processing in plants. Marchant A, et al. Plant Mol Biol, 1998 Feb. PMID 9484486
    4. Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex. Swarup R, et al. Genes Dev, 2001 Oct 15. PMID 11641271, Free PMC Article
    5. High-affinity auxin transport by the AUX1 influx carrier protein. Yang Y, et al. Curr Biol, 2006 Jun 6. PMID 16677815

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Auxin resistant 1 gene (AUX1) mediates auxin effect on Arabidopsis thaliana callus growth by regulating its content and distribution pattern.
      Title: Auxin resistant 1 gene (AUX1) mediates auxin effect on Arabidopsis thaliana callus growth by regulating its content and distribution pattern.
    2. Mechanistic insight into the role of AUXIN RESISTANCE4 in trafficking of AUXIN1 and LIKE AUX1-2.
      Title: Mechanistic insight into the role of AUXIN RESISTANCE4 in trafficking of AUXIN1 and LIKE AUX1-2.
    3. AUX1, PIN3, and TAA1 collectively maintain fertility in Arabidopsis.
      Title: AUX1, PIN3, and TAA1 collectively maintain fertility in Arabidopsis.
    4. Auxin-induced actin cytoskeleton rearrangements require AUX1.
      Title: Auxin-induced actin cytoskeleton rearrangements require AUX1.
    5. Molecular determinants of potassium stimulation of indole-3-acetic acid transport mediated by the Arabidopsis Importer AUX1 investigated in a heterologous yeast system have been reported.
      Title: Potassium Stimulation of IAA Transport Mediated by the Arabidopsis Importer AUX1 Investigated in a Heterologous Yeast System.
    6. The structure activity relationship data were analysed using molecular field analyses to create a pharmacophoric atlas of AUX1 substrates.
      Title: Auxin molecular field maps define AUX1 selectivity: many auxin herbicides are not substrates.
    7. ethylene mediates hexavalent form of chromium-induced inhibition of primary root elongation by increasing auxin accumulation and polar transport by stimulating the expression of AUX1.
      Title: Ethylene mediates dichromate-induced inhibition of primary root growth by altering AUX1 expression and auxin accumulation in Arabidopsis thaliana.
    8. These findings support AUX1 plays a role in root gravitropism upstream of PIN2.
      Title: AUX1 acts upstream of PIN2 in regulating root gravitropism.
    9. AUX1-mediated root hair auxin influx governs SCF-type calcium signaling.
      Title: AUX1-mediated root hair auxin influx governs SCF(TIR1/AFB)-type Ca(2+) signaling.
    10. RopGEF1 is critical for AUX1 localization.
      Title: RopGEF1 Plays a Critical Role in Polar Auxin Transport in Early Development.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001336689.1
    NM_129368.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables auxin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables auxin influx transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within amino acid transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within auxin polar transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of planar polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lateral root formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lateral root formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive gravitropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within response to ethylene NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within response to nematode HEP PubMed 
    acts_upstream_of_or_within root cap development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within somatic embryogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within somatic embryogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Transmembrane amino acid transporter family protein
    NP_565882.1
    • AUXIN RESISTANT 1 (AUX1); CONTAINS InterPro DOMAIN/s: Amino acid transporter, transmembrane (InterPro:IPR013057); BEST Arabidopsis thaliana protein match is: like AUXIN RESISTANT 1 (TAIR:AT5G01240.1); Has 1256 Blast hits to 1251 proteins in 143 species: Archae - 0; Bacteria - 0; Metazoa - 116; Fungi - 283; Plants - 825; Viruses - 0; Other Eukaryotes - 32 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15972876..15977180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129368.3 → NP_565882.1  Transmembrane amino acid transporter family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565882.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q96247
      UniProtKB/TrEMBL
      A0A178VZ45, A0A5S9X514
      Conserved Domains (1) summary
      PLN03074
      Location:2 → 469
      PLN03074; auxin influx permease; Provisional

    2. NM_001336689.1 → NP_001324970.1  Transmembrane amino acid transporter family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B1Q8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96247.1

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