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    PMDH1 peroxisomal NAD-malate dehydrogenase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816808, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PMDH1
    Official Full Name
    peroxisomal NAD-malate dehydrogenase 1
    Primary source
    TAIR:AT2G22780
    Locus tag
    AT2G22780
    See related
    Araport:AT2G22780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    peroxisomal NAD-malate dehydrogenase 1; T30L20.4; T30L20_4
    Summary
    encodes an peroxisomal NAD-malate dehydrogenase that is involved in fatty acid beta-oxidation through providing NAD to the process of converting fatty acyl CoA to acetyl CoA.
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    Genomic context

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    See PMDH1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (9689295..9692154, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Peroxisomal malate dehydrogenase is not essential for photorespiration in Arabidopsis but its absence causes an increase in the stoichiometry of photorespiratory CO2 release. Cousins AB, et al. Plant Physiol, 2008 Oct. PMID 18685043, Free PMC Article
    2. Arabidopsis peroxisomal malate dehydrogenase functions in beta-oxidation but not in the glyoxylate cycle. Pracharoenwattana I, et al. Plant J, 2007 May. PMID 17376163
    3. Proteomic analysis of leaf peroxisomal proteins in greening cotyledons of Arabidopsis thaliana. Fukao Y, et al. Plant Cell Physiol, 2002 Jul. PMID 12154131
    4. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article
    5. Identification and characterization of nuclear pore complex components in Arabidopsis thaliana. Tamura K, et al. Plant Cell, 2010 Dec. PMID 21189294, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutation of pmdh1 and pmdh2 causes somewhat reduced photosynthesis but increases the amount of CO2 released during photorespiration.
      Title: Peroxisomal malate dehydrogenase is not essential for photorespiration in Arabidopsis but its absence causes an increase in the stoichiometry of photorespiratory CO2 release.
    2. The function of PEROXISOMAL NAD-MALATE DEHYDROGENASE 1 and PEROXISOMAL NAD-MALATE DEHYDROGENASE 2 in fatty acid beta-oxidation and the glyoxylate cycle in Arabidopsis are reported.
      Title: Arabidopsis peroxisomal malate dehydrogenase functions in beta-oxidation but not in the glyoxylate cycle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_127843.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-malate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in malate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of fatty acid beta-oxidation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of photorespiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome HDA PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxisomal NAD-malate dehydrogenase 1
    NP_179863.1
    • peroxisomal NAD-malate dehydrogenase 1 (PMDH1); FUNCTIONS IN: in 6 functions; INVOLVED IN: regulation of fatty acid beta-oxidation, regulation of photorespiration; LOCATED IN: chloroplast, peroxisome; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Lactate/malate dehydrogenase, N-terminal (InterPro:IPR001236), Lactate/malate dehydrogenase, C-terminal (InterPro:IPR022383), NAD(P)-binding domain (InterPro:IPR016040), Malate dehydrogenase, NAD-dependent, eukaryote/gamma proteobacteria (InterPro:IPR010097), L-lactate/malate dehydrogenase (InterPro:IPR001557), Malate dehydrogenase, active site (InterPro:IPR001252), Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (InterPro:IPR015955); BEST Arabidopsis thaliana protein match is: peroxisomal NAD-malate dehydrogenase 2 (TAIR:AT5G09660.1); Has 16991 Blast hits to 16989 proteins in 5457 species: Archae - 237; Bacteria - 11827; Metazoa - 1259; Fungi - 489; Plants - 758; Viruses - 0; Other Eukaryotes - 2421 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9689295..9692154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127843.5 → NP_179863.1  peroxisomal NAD-malate dehydrogenase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179863.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82399
      UniProtKB/TrEMBL
      A0A178VML0, A0A384LAR8, A0A7G2E8A0, Q0WUS4
      Conserved Domains (1) summary
      PLN00106
      Location:33 → 347
      PLN00106; malate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82399.1

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