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    AT-P4H-1 P4H isoform 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818910, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AT-P4H-1
    Official Full Name
    P4H isoform 1
    Primary source
    TAIR:AT2G43080
    Locus tag
    AT2G43080
    See related
    Araport:AT2G43080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    P4H isoform 1; PROLYL 4-HYDROXYLASE
    Summary
    Encodes a prolyl-4 hydroxylase that can hydroxylate poly(L-proline),the collagen model peptide (Pro-Pro-Gly)10 and other proline rich peptides.
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    Genomic context

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    See AT-P4H-1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Sequence:
    Chromosome: 2; NC_003071.7 (17915448..17918826)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ILI1 binding bHLH 1 Neighboring gene SIGNAL PEPTIDE PEPTIDASE-LIKE 3 Neighboring gene Aconitase/3-isopropylmalate dehydratase protein Neighboring gene isopropylmalate isomerase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prolyl-4-hydroxylase (AtP4H1) mediates and mimics low oxygen response in Arabidopsis thaliana. Asif MH, et al. Funct Integr Genomics, 2009 Nov. PMID 19277739
    2. Cloning and characterization of a low molecular weight prolyl 4-hydroxylase from Arabidopsis thaliana. Effective hydroxylation of proline-rich, collagen-like, and hypoxia-inducible transcription factor alpha-like peptides. Hieta R, et al. J Biol Chem, 2002 Jun 28. PMID 11976332
    3. Separating Golgi Proteins from Cis to Trans Reveals Underlying Properties of Cisternal Localization. Parsons HT, et al. Plant Cell, 2019 Sep. PMID 31266899, Free PMC Article
    4. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Parsons HT, et al. Plant Physiol, 2012 May. PMID 22430844, Free PMC Article
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest a direct role of AtP4H1 in hypoxia stress and in different stages of plant growth and development.
      Title: Prolyl-4-hydroxylase (AtP4H1) mediates and mimics low oxygen response in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001337014.1
    NM_129869.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within peptidyl-proline hydroxylation to 4-hydroxy-L-proline IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi cis cisterna HDA PubMed 
    located_in Golgi cis cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    P4H isoform 1
    NP_181836.1
    • P4H isoform 1 (AT-P4H-1); FUNCTIONS IN: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, procollagen-proline 4-dioxygenase activity; INVOLVED IN: peptidyl-proline hydroxylation to 4-hydroxy-L-proline; LOCATED IN: endomembrane system; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Prolyl 4-hydroxylase, alpha subunit (InterPro:IPR006620), Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein (TAIR:AT1G20270.1); Has 2440 Blast hits to 2431 proteins in 340 species: Archae - 0; Bacteria - 392; Metazoa - 982; Fungi - 96; Plants - 404; Viruses - 14; Other Eukaryotes - 552 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17915448..17918826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129869.5 → NP_181836.1  P4H isoform 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181836.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZW86
      UniProtKB/TrEMBL
      A0A178VYT9, A0A5S9X6L5, A0A654F2N2
      Conserved Domains (1) summary
      PLN00052
      Location:80 → 281
      PLN00052; prolyl 4-hydroxylase; Provisional

    2. NM_001337014.1 → NP_001324186.1  P4H isoform 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AZF5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZW86.1

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