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    MYB60 myb domain protein 60 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837403, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MYB60
    Official Full Name
    myb domain protein 60
    Primary source
    TAIR:AT1G08810
    Locus tag
    AT1G08810
    See related
    Araport:AT1G08810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtMYB60; F22O13.30; F22O13_30; myb domain protein 60
    Summary
    putative transcription factor of the R2R3-MYB gene family. Transcript increases under conditions that promote stomatal opening (white and blue light, abi1-1 mutation) and decreases under conditions that trigger stomatal closure (ABA, desiccation, darkness), with the exception of elevated CO2. Expressed exclusively in guard cells of all tissues. It is required for light-induced opening of stomata. Mutant shows reduced stomatal aperture which helps to limit water loss during drought.
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    Genomic context

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    See MYB60 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (2819065..2820478, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1, putative (DUF1685) Neighboring gene myosin-binding protein (Protein of unknown function, DUF593) Neighboring gene vamp/synaptobrevin-associated protein 27-2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The AtMYB60 transcription factor regulates stomatal opening by modulating oxylipin synthesis in guard cells. Simeoni F, et al. Sci Rep, 2022 Jan 11. PMID 35017563, Free PMC Article
    2. DOF-binding sites additively contribute to guard cell-specificity of AtMYB60 promoter. Cominelli E, et al. BMC Plant Biol, 2011 Nov 16. PMID 22088138, Free PMC Article
    3. A dual role for MYB60 in stomatal regulation and root growth of Arabidopsis thaliana under drought stress. Oh JE, et al. Plant Mol Biol, 2011 Sep. PMID 21637967
    4. Arabidopsis R2R3-MYB transcription factor AtMYB60 functions as a transcriptional repressor of anthocyanin biosynthesis in lettuce (Lactuca sativa). Park JS, et al. Plant Cell Rep, 2008 Jun. PMID 18317777, Free PMC Article
    5. A guard-cell-specific MYB transcription factor regulates stomatal movements and plant drought tolerance. Cominelli E, et al. Curr Biol, 2005 Jul 12. PMID 16005291

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The AtMYB60 transcription factor regulates stomatal opening by modulating oxylipin synthesis in guard cells.
      Title: The AtMYB60 transcription factor regulates stomatal opening by modulating oxylipin synthesis in guard cells.
    2. DOF-binding sites are required for AtMYB60 guard-cells expression.
      Title: DOF-binding sites additively contribute to guard cell-specificity of AtMYB60 promoter.
    3. MYB60 plays a dual role in abiotic stress responses in Arabidopsis through its involvement in stomatal regulation and root growth.
      Title: A dual role for MYB60 in stomatal regulation and root growth of Arabidopsis thaliana under drought stress.
    4. Results demonstrate that phyB and CRY might regulate stomatal opening, at least in part, by regulating MYB60 expression.
      Title: Phytochrome B is involved in mediating red light-induced stomatal opening in Arabidopsis thaliana.
    5. Overexpression of transcription factor AtMYB60 represses anthocyanin biosynthesis in lettuce.
      Title: Arabidopsis R2R3-MYB transcription factor AtMYB60 functions as a transcriptional repressor of anthocyanin biosynthesis in lettuce (Lactuca sativa).
    6. AtMYB60 regulates stomatal movements and plant drought tolerance as a transcriptional modulator of physiological responses in guard cells.
      Title: A guard-cell-specific MYB transcription factor regulates stomatal movements and plant drought tolerance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001331790.1
    NM_100755.3
    NM_202066.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to UV IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to absence of light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to auxin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to blue light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to salt IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to sucrose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    myb domain protein 60
    NP_001318958.1
    • myb domain protein 60 (MYB60); CONTAINS InterPro DOMAIN/s: Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287), Myb transcription factor (InterPro:IPR015495); BEST Arabidopsis thaliana protein match is: myb domain protein 96 (TAIR:AT5G62470.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_172358.1
    • myb domain protein 60 (MYB60); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287), Myb transcription factor (InterPro:IPR015495); BEST Arabidopsis thaliana protein match is: myb domain protein 96 (TAIR:AT5G62470.2); Has 8826 Blast hits to 8217 proteins in 521 species: Archae - 0; Bacteria - 0; Metazoa - 784; Fungi - 468; Plants - 5803; Viruses - 7; Other Eukaryotes - 1764 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2819065..2820478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100755.3 → NP_172358.1  myb domain protein 60 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172358.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D2CFP9, Q3E6Y6, Q8GYP5, Q9FRQ8, Q9SBG0
      UniProtKB/TrEMBL
      A0A178WD25, A0A5S9TCK3
      Conserved Domains (1) summary
      PLN03212
      Location:5 → 125
      PLN03212; Transcription repressor MYB5; Provisional

    2. NM_001331790.1 → NP_001318958.1  myb domain protein 60 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q3E6Y6
      Conserved Domains (1) summary
      PLN03212
      Location:5 → 42
      PLN03212; Transcription repressor MYB5; Provisional

    3. NM_202066.1 → NP_973795.1  myb domain protein 60 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973795.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q3E6Y6
      Conserved Domains (1) summary
      PLN03212
      Location:5 → 42
      PLN03212; Transcription repressor MYB5; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GYP5.1

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