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    CDT1A CDT1-like protein A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817684, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CDT1A
    Official Full Name
    CDT1-like protein A
    Primary source
    TAIR:AT2G31270
    Locus tag
    AT2G31270
    See related
    Araport:AT2G31270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS HOMOLOG OF YEAST CDT1; ARABIDOPSIS HOMOLOG OF YEAST CDT1 A; ATCDT1A; CDT1; F16D14.11; F16D14_11; homolog of yeast CDT1 A
    Summary
    Encodes a cyclin-dependent protein kinase. Involved in nuclear DNA replication and plastid division. Located in nucleus and chloroplast.
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    Genomic context

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    See CDT1A in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (13328862..13331831)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Glutamyl-tRNA reductase family protein Neighboring gene uncharacterized protein Neighboring gene autophagy 9 (APG9) Neighboring gene transcription factor bHLH155-like protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase family protein Neighboring gene actin-related protein C1B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for a role of Arabidopsis CDT1 proteins in gametophyte development and maintenance of genome integrity. Domenichini S, et al. Plant Cell, 2012 Jul. PMID 22773747, Free PMC Article
    2. Genome based identification and analysis of the pre-replicative complex of Arabidopsis thaliana. Masuda HP, et al. FEBS Lett, 2004 Sep 10. PMID 15358564
    3. Cell and plastid division are coordinated through the prereplication factor AtCDT1. Raynaud C, et al. Proc Natl Acad Sci U S A, 2005 Jun 7. PMID 15928083, Free PMC Article
    4. A chromatin link that couples cell division to root epidermis patterning in Arabidopsis. Caro E, et al. Nature, 2007 May 10. PMID 17450124
    5. DNA replication licensing affects cell proliferation or endoreplication in a cell type-specific manner. Castellano Mdel M, et al. Plant Cell, 2004 Sep. PMID 15316110, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis CDT1 proteins played a crucial role in genome stability.
      Title: Evidence for a role of Arabidopsis CDT1 proteins in gametophyte development and maintenance of genome integrity.
    2. Down-regulation of AtCDT1a and AtCDT1b, members of the prereplication complex, is shown to alter both nuclear DNA replication and plastid division in Arabidopsis thaliana [CDT1a]
      Title: Cell and plastid division are coordinated through the prereplication factor AtCDT1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_128683.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gametophyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    CDT1-like protein A
    NP_180685.1
    • homolog of yeast CDT1 A (CDT1A); FUNCTIONS IN: protein binding, cyclin-dependent protein kinase activity; INVOLVED IN: chloroplast organization, DNA replication; LOCATED IN: chloroplast, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA replication factor CDT1-like (InterPro:IPR014939); BEST Arabidopsis thaliana protein match is: homolog of yeast CDT1 B homolog of yeast CDT1 B (TAIR:AT3G54710.1); Has 1317 Blast hits to 1078 proteins in 213 species: Archae - 6; Bacteria - 83; Metazoa - 600; Fungi - 201; Plants - 122; Viruses - 41; Other Eukaryotes - 264 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      13328862..13331831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128683.4 → NP_180685.1  CDT1-like protein A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180685.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q710F0, Q8L7I6, Q9SJW9
      UniProtKB/TrEMBL
      A0A178VV32
      Conserved Domains (2) summary
      cd08674
      Location:107 → 234
      Cdt1_m; The middle winged helix fold of replication licensing factor Cdt1 binds geminin to inhibit binding of the MCM complex to origins of replication and DNA
      cd08767
      Location:433 → 559
      Cdt1_c; The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SJW9.1

    Gene LinkOut

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