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    MST1 mercaptopyruvate sulfurtransferase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844264, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MST1
    Official Full Name
    mercaptopyruvate sulfurtransferase 1
    Primary source
    TAIR:AT1G79230
    Locus tag
    AT1G79230
    See related
    Araport:AT1G79230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA RHODANESE HOMOLOGUE 1; ATMST1; ATRDH1; MERCAPTOPYRUVATE SULFURTRANSFERASE; mercaptopyruvate sulfurtransferase 1; ST1; STR1; SULFURTRANSFERASE 1; YUP8H12R.17; YUP8H12R_17
    Summary
    encodes a sulfurtransferase/rhodaneses, which belongs to a group of enzymes widely distributed in all three phyla that catalyze the transfer of sulfur from a donor to a thiophilic acceptor substrate. The protein and transcript levels are NOT affected by senescence or exogenous cyanide, suggesting that sulfurtransferases are involved in cyanide detoxification.
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    Genomic context

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    See MST1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (29800563..29804033)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ARM repeat superfamily protein Neighboring gene splicing regulatory glutamine/lysine-rich-like protein Neighboring gene N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein Neighboring gene Mitochondrial transcription termination factor family protein Neighboring gene tRNA-Arg Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enzymatic activity of the Arabidopsis sulfurtransferase resides in the C-terminal domain but is boosted by the N-terminal domain and the linker peptide in the full-length enzyme. Burow M, et al. Biol Chem, 2002 Sep. PMID 12437129
    2. Sulfurtransferases 1 and 2 play essential roles in embryo and seed development in Arabidopsis thaliana. Mao G, et al. J Biol Chem, 2011 Mar 4. PMID 21189252, Free PMC Article
    3. Plant mercaptopyruvate sulfurtransferases: molecular cloning, subcellular localization and enzymatic activities. Nakamura T, et al. Eur J Biochem, 2000 Sep. PMID 10951223
    4. Evidence for the existence of rhodanese (thiosulfate:cyanide sulfurtransferase) in plants: preliminary characterization of two rhodanese cDNAs from Arabidopsis thaliana. Hatzfeld Y, et al. FEBS Lett, 2000 Mar 24. PMID 10734224
    5. Analysis of the Arabidopsis mitochondrial proteome. Millar AH, et al. Plant Physiol, 2001 Dec. PMID 11743115, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The incomplete penetrance of str1 embryo/seed phenotype is a result of functional STR2
      Title: Sulfurtransferases 1 and 2 play essential roles in embryo and seed development in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001084378.1
    NM_001084379.1
    NM_106574.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3-mercaptopyruvate sulfurtransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfurtransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thiosulfate sulfurtransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thiosulfate sulfurtransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiosulfate sulfurtransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    mercaptopyruvate sulfurtransferase 1
    NP_001077847.1
    • mercaptopyruvate sulfurtransferase 1 (MST1); FUNCTIONS IN: 3-mercaptopyruvate sulfurtransferase activity, sulfurtransferase activity, thiosulfate sulfurtransferase activity; INVOLVED IN: sulfate transport, aging; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Rhodanese-like (InterPro:IPR001763), Thiosulphate sulfurtransferase, conserved site (InterPro:IPR001307); BEST Arabidopsis thaliana protein match is: rhodanese homologue 2 (TAIR:AT1G16460.2); Has 5492 Blast hits to 5485 proteins in 1417 species: Archae - 139; Bacteria - 3460; Metazoa - 262; Fungi - 144; Plants - 91; Viruses - 0; Other Eukaryotes - 1396 (source: NCBI BLink).
    NP_001077848.1
    • mercaptopyruvate sulfurtransferase 1 (MST1); FUNCTIONS IN: 3-mercaptopyruvate sulfurtransferase activity, sulfurtransferase activity, thiosulfate sulfurtransferase activity; INVOLVED IN: sulfate transport, aging; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Rhodanese-like (InterPro:IPR001763), Thiosulphate sulfurtransferase, conserved site (InterPro:IPR001307); BEST Arabidopsis thaliana protein match is: rhodanese homologue 2 (TAIR:AT1G16460.2); Has 6251 Blast hits to 6226 proteins in 1459 species: Archae - 162; Bacteria - 3623; Metazoa - 283; Fungi - 152; Plants - 95; Viruses - 0; Other Eukaryotes - 1936 (source: NCBI BLink).
    NP_565203.1
    • mercaptopyruvate sulfurtransferase 1 (MST1); FUNCTIONS IN: 3-mercaptopyruvate sulfurtransferase activity, sulfurtransferase activity, thiosulfate sulfurtransferase activity; INVOLVED IN: sulfate transport, aging; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Rhodanese-like (InterPro:IPR001763), Thiosulphate sulfurtransferase, conserved site (InterPro:IPR001307); BEST Arabidopsis thaliana protein match is: rhodanese homologue 2 (TAIR:AT1G16460.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29800563..29804033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106574.3 → NP_565203.1  mercaptopyruvate sulfurtransferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565203.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MSC9, O64530, Q9SCY8
      UniProtKB/TrEMBL
      A0A5S9WVP6, A0A654EQI8
      Conserved Domains (1) summary
      PLN02723
      Location:58 → 377
      PLN02723; 3-mercaptopyruvate sulfurtransferase

    2. NM_001084379.1 → NP_001077848.1  mercaptopyruvate sulfurtransferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077848.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WKK0
      Conserved Domains (1) summary
      PLN02723
      Location:1 → 320
      PLN02723; 3-mercaptopyruvate sulfurtransferase

    3. NM_001084378.1 → NP_001077847.1  mercaptopyruvate sulfurtransferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077847.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8MR47
      Conserved Domains (2) summary
      cd01449
      Location:153 → 268
      TST_Repeat_2; Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue.
      cl00125
      Location:83 → 106
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64530.1

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