GSL8 glucan synthase-like 8 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GSL8
Official Full Name: glucan synthase-like 8
Primary source: TAIR:AT2G36850
Locus tag: AT2G36850
See related: Araport:AT2G36850
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATGSL08; ATGSL8; CHOR; CHORUS; ENLARGED TETRAD 2; ET2; glucan synthase-like 8; GLUCAN SYNTHASE-LIKE 8; GSL08; MAS; MASSUE; T1J8.3; T1J8_3
Summary: Encodes GSL8, a member of the Glucan Synthase-Like (GSL) family believed to be involved in the synthesis of the cell wall component callose. GSL8 is required for male gametophyte development and plant growth. Has a role in entry of microspores into mitosis. Also refer to GSL10 (At3g07160).
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Genomic context

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See GSL8 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 50

Sequence:: Chromosome: 2; NC_003071.7 (15454671..15469964, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a new allele of GSL8 (named essp8) that exhibits pleiotropic seedling defects
Title: Analysis of a novel mutant allele of GSL8 reveals its key roles in cytokinesis and symplastic trafficking in Arabidopsis.
GSL8 and SMT2 proteins are required for ploidy consistency of the sexual reproduction system in Arabidopsis.
Title: GLUCAN SYNTHASE-LIKE8 and STEROL METHYLTRANSFERASE2 are required for ploidy consistency of the sexual reproduction system in Arabidopsis.
GSL8 is essential for the completion of plant cytokinesis.
Title: The timely deposition of callose is essential for cytokinesis in Arabidopsis.
Dysregulation of cell-to-cell connectivity and stomatal patterning by loss-of-function mutation in Arabidopsis CHORUS (GLUCAN SYNTHASE-LIKE 8).
Title: Dysregulation of cell-to-cell connectivity and stomatal patterning by loss-of-function mutation in Arabidopsis chorus (glucan synthase-like 8).
GSL8 is required for patterning as well as cytokinesis during Arabidopsis development.
Title: The Arabidopsis callose synthase gene GSL8 is required for cytokinesis and cell patterning.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_179940.6

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 1,3-beta-D-glucan synthase activity	IEA Inferred from Electronic Annotation more info
enables 1,3-beta-D-glucan synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in (1->3)-beta-D-glucan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in callose deposition in cell wall	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microsporogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of 1,3-beta-D-glucan synthase complex	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	HDA more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in plasma membrane	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: glucan synthase-like 8

NP_850271.5

glucan synthase-like 8 (GSL8); FUNCTIONS IN: transferase activity, transferring glycosyl groups, 1,3-beta-glucan synthase activity; INVOLVED IN: microsporogenesis, 1,3-beta-glucan biosynthetic process, pollen development, developmental growth; LOCATED IN: 1,3-beta-glucan synthase complex, plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 48 (InterPro:IPR003440); BEST Arabidopsis thaliana protein match is: glucan synthase-like 10 (TAIR:AT3G07160.1); Has 1219 Blast hits to 893 proteins in 146 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 675; Plants - 477; Viruses - 0; Other Eukaryotes - 67 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

15454671..15469964 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_179940.6 → NP_850271.5 glucan synthase-like 8 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850271.5

Status: REVIEWED

UniProtKB/Swiss-Prot

C8C9X2, Q0WN58, Q9SJM0

UniProtKB/TrEMBL

A0A178VPS0, A0A5S9X4L8, A0A654EZK1

Conserved Domains (2) summary

pfam02364
Location:1027 → 1734

Glucan_synthase; 1,3-beta-glucan synthase component

pfam14288
Location:345 → 457

FKS1_dom1; 1,3-beta-glucan synthase subunit FKS1, domain-1