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    RNR1 ribonucleotide reductase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816715, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RNR1
    Official Full Name
    ribonucleotide reductase 1
    Primary source
    TAIR:AT2G21790
    Locus tag
    AT2G21790
    See related
    Araport:AT2G21790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRNR1; CLS8; CRINKLY LEAVES 8; defective in pollen organelle DNA degradation 2; DPD2; R1; ribonucleotide reductase 1; RIBONUCLEOTIDE REDUCTASE 1; RIBONUCLEOTIDE REDUCTASE LARGE SUBUNIT 1
    Summary
    encodes large subunit of ribonucleotide reductase involved in the production of deoxyribonucleoside triphosphates (dNTPs) for DNA replication and repair
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    Genomic context

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    See RNR1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Sequence:
    Chromosome: 2; NC_003071.7 (9293261..9297861)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene cellulose synthase A9 Neighboring gene uncharacterized protein Neighboring gene essential meiotic endonuclease 1A Neighboring gene Cysteine/Histidine-rich C1 domain family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ribonuclease II preserves chloroplast RNA homeostasis by increasing mRNA decay rates, and cooperates with polynucleotide phosphorylase in 3' end maturation. Germain A, et al. Plant J, 2012 Dec. PMID 23061883
    2. crinkled leaves 8--a mutation in the large subunit of ribonucleotide reductase--leads to defects in leaf development and chloroplast division in Arabidopsis thaliana. Garton S, et al. Plant J, 2007 Apr. PMID 17346262
    3. Mutations defective in ribonucleotide reductase activity interfere with pollen plastid DNA degradation mediated by DPD1 exonuclease. Tang LY, et al. Plant J, 2012 May. PMID 22239102
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cooperative activity of two 3'-->5' exoribonucleases in chloroplast mRNA 3' end maturation, and support the hypothesis that RNR1 plays a significant role in the destabilization of mRNAs unprotected by ribosomes.
      Title: Ribonuclease II preserves chloroplast RNA homeostasis by increasing mRNA decay rates, and cooperates with polynucleotide phosphorylase in 3' end maturation.
    2. Data show that the defects in ribonucleotide reductase DPD2 (At2g21790) indirectly compromise the activity of DPD1 nuclease (At5g26940) in plastids, suggesting a different regulation of organellar DNA degradation in pollen.
      Title: Mutations defective in ribonucleotide reductase activity interfere with pollen plastid DNA degradation mediated by DPD1 exonuclease.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_127748.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within deoxyribonucleoside triphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in deoxyribonucleotide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ribonucleotide reductase 1
    NP_179770.1
    • ribonucleotide reductase 1 (RNR1); FUNCTIONS IN: ribonucleoside-diphosphate reductase activity, ATP binding; INVOLVED IN: response to cadmium ion, DNA replication, deoxyribonucleoside triphosphate biosynthetic process; LOCATED IN: ribonucleoside-diphosphate reductase complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ribonucleotide reductase large subunit, N-terminal (InterPro:IPR013509), Ribonucleoside-diphosphate reductase, alpha subunit (InterPro:IPR013346), ATP-cone (InterPro:IPR005144), Ribonucleotide reductase large subunit, C-terminal (InterPro:IPR000788), Ribonucleotide reductase R1 subunit, N-terminal (InterPro:IPR008926); Has 15326 Blast hits to 14804 proteins in 2790 species: Archae - 206; Bacteria - 6388; Metazoa - 177; Fungi - 215; Plants - 88; Viruses - 606; Other Eukaryotes - 7646 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9293261..9297861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127748.4 → NP_179770.1  ribonucleotide reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179770.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82573, Q9SJ20
      UniProtKB/TrEMBL
      A0A178VR42, A0A5S9X060, A0A654EUW8
      Conserved Domains (1) summary
      PLN02437
      Location:1 → 816
      PLN02437; ribonucleoside--diphosphate reductase large subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SJ20.1

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