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    ADS2 16:0delta9 desaturase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817694, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ADS2
    Official Full Name
    16:0delta9 desaturase 2
    Primary source
    TAIR:AT2G31360
    Locus tag
    AT2G31360
    See related
    Araport:AT2G31360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    16:0delta9 desaturase 2; AtADS2; DELTA 9 DESATURASE; T28P16.15; T28P16_15
    Summary
    Encodes a protein homologous to delta 9 acyl-lipid desaturases of cyanobacteria and acyl-CoA desaturases of yeast and mammals. expression up-regulated by cold temperature. It is involved in the synthesis of the 24:1n-9 and 26:1n-9 components of seed lipids, sphingolipids and the membrane phospholipids phosphatidylserine (PS), and phosphatidylethanolamine (PE).
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    Genomic context

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    See ADS2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (13371658..13374018, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene embryo defective 1381 Neighboring gene uncharacterized protein Neighboring gene glyoxalase 2-5 Neighboring gene Basic-leucine zipper (bZIP) transcription factor family protein Neighboring gene pfkB-like carbohydrate kinase family protein Neighboring gene salt tolerance homologue

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ACYL-LIPID DESATURASE2 is required for chilling and freezing tolerance in Arabidopsis. Chen M, et al. Plant Cell, 2013 Apr. PMID 23585650, Free PMC Article
    2. Involvement of Arabidopsis ACYL-COENZYME A DESATURASE-LIKE2 (At2g31360) in the biosynthesis of the very-long-chain monounsaturated fatty acid components of membrane lipids. Smith MA, et al. Plant Physiol, 2013 Jan. PMID 23175755, Free PMC Article
    3. Integrative analysis of transcript and metabolite profiling data sets to evaluate the regulation of biochemical pathways during photomorphogenesis. Ghassemian M, et al. Arch Biochem Biophys, 2006 Apr 15. PMID 16460663
    4. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article
    5. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that ADS2 is essential to adjust the acyl composition of organelle membrane lipid composition in response to cold stress.
      Title: ACYL-LIPID DESATURASE2 is required for chilling and freezing tolerance in Arabidopsis.
    2. AtADS2 is involved in the synthesis of glycerolipid and sphingolipids in the seed.
      Title: Involvement of Arabidopsis ACYL-COENZYME A DESATURASE-LIKE2 (At2g31360) in the biosynthesis of the very-long-chain monounsaturated fatty acid components of membrane lipids.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_128693.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to red light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in unsaturated fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within very long-chain fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    16:0delta9 desaturase 2
    NP_565721.1
    • 16:0delta9 desaturase 2 (DS2); FUNCTIONS IN: oxidoreductase activity, oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; INVOLVED IN: oxidation reduction, lipid metabolic process; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Fatty acid desaturase, type 1, core (InterPro:IPR015876), Fatty acid desaturase, type 1 (InterPro:IPR005804); BEST Arabidopsis thaliana protein match is: delta 9 desaturase 1 (TAIR:AT1G06080.1); Has 3454 Blast hits to 3454 proteins in 832 species: Archae - 0; Bacteria - 1553; Metazoa - 797; Fungi - 236; Plants - 106; Viruses - 4; Other Eukaryotes - 758 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      13371658..13374018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336328.1 → NP_001323798.1  16:0delta9 desaturase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65798, Q8LD80, Q9SID2
      UniProtKB/TrEMBL
      A0A178VRL6, A0A5S9X310
      Conserved Domains (1) summary
      PLN02220
      Location:1 → 307
      PLN02220; delta-9 acyl-lipid desaturase

    2. NM_128693.5 → NP_565721.1  16:0delta9 desaturase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565721.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65798, Q8LD80, Q9SID2
      UniProtKB/TrEMBL
      A0A178VRL6, A0A5S9X310
      Conserved Domains (1) summary
      PLN02220
      Location:1 → 307
      PLN02220; delta-9 acyl-lipid desaturase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SID2.2

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