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    SCO1 Translation elongation factor EFG/EF2 protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842573, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SCO1
    Official Full Name
    Translation elongation factor EFG/EF2 protein
    Primary source
    TAIR:AT1G62750
    Locus tag
    AT1G62750
    See related
    Araport:AT1G62750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSCO1; ATSCO1/CPEF-G; F23N19.11; F23N19_11; SNOWY COTYLEDON 1
    Summary
    Nuclear encoded protein consists of the five domains conserved in EF-G proteins, with two GTP-binding sites in the first domain, and an additional transit peptide at the N-terminus. Localized in chloroplasts. Point mutation results in a delay in the onset of germination. At early developmental stage embryos still contain undifferentiated proplastids. The greening of cotyledons is severely impaired in light-grown mutant sco1 seedlings, whereas the following true leaves develop normally as in wild-type plants.
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    Genomic context

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    See SCO1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (23233434..23236447, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Pentatricopeptide repeat (PPR-like) superfamily protein Neighboring gene Terpenoid synthases superfamily protein Neighboring gene stress-inducible protein Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in a plastid-localized elongation factor G alter early stages of plastid development in Arabidopsis thaliana. Ruppel NJ, et al. BMC Plant Biol, 2007 Jul 13. PMID 17629920, Free PMC Article
    2. Characterization of the snowy cotyledon 1 mutant of Arabidopsis thaliana: the impact of chloroplast elongation factor G on chloroplast development and plant vitality. Albrecht V, et al. Plant Mol Biol, 2006 Mar. PMID 16525888
    3. Analysis of the soluble ATP-binding proteome of plant mitochondria identifies new proteins and nucleotide triphosphate interactions within the matrix. Ito J, et al. J Proteome Res, 2006 Dec. PMID 17137349
    4. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804
    5. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Seedlings with mutant alleles of SCO1 exhibit cotyledon and hypocotyl albinism due to improper chloroplast development, and normally die shortly after germination making SCO1 essential for plant growth.
      Title: Mutations in a plastid-localized elongation factor G alter early stages of plastid development in Arabidopsis thaliana.
    2. SCO1 encodes a chloroplast-localized elongation factor G. If mutated, the gene affects the chloroplast mRNA translation. [snowy cotyledon 1] [AtSCO1]
      Title: Characterization of the snowy cotyledon 1 mutant of Arabidopsis thaliana: the impact of chloroplast elongation factor G on chloroplast development and plant vitality.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_104952.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Translation elongation factor EFG/EF2 protein
    NP_564801.1
    • SNOWY COTYLEDON 1 (SCO1); FUNCTIONS IN: translation factor activity, nucleic acid binding, GTP binding, translation elongation factor activity, ATP binding; INVOLVED IN: post-embryonic development, chloroplast organization, seed germination; LOCATED IN: mitochondrion, apoplast, chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein synthesis factor, GTP-binding (InterPro:IPR000795), Translation elongation factor EFG/EF2, domain IV (InterPro:IPR005517), Small GTP-binding protein (InterPro:IPR005225), Translation elongation factor EFTu/EF1A, domain 2 (InterPro:IPR004161), Translation elongation factor EFG/EF2, C-terminal (InterPro:IPR000640), Translation elongation factor EFG/EF2 (InterPro:IPR004540), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721), Elongation factor G/III/V (InterPro:IPR009022), Translation elongation/initiation factor/Ribosomal, beta-barrel (InterPro:IPR009000); BEST Arabidopsis thaliana protein match is: Translation elongation factor EFG/EF2 protein (TAIR:AT2G45030.1); Has 79823 Blast hits to 67706 proteins in 7071 species: Archae - 929; Bacteria - 47320; Metazoa - 4453; Fungi - 5428; Plants - 1613; Viruses - 3; Other Eukaryotes - 20077 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      23233434..23236447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104952.2 → NP_564801.1  Translation elongation factor EFG/EF2 protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564801.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94BR7, Q9SI75
      UniProtKB/TrEMBL
      A0A178WCD2, A0A5S9WS08, A0A654EW54
      Conserved Domains (1) summary
      PRK00007
      Location:89 → 777
      PRK00007; elongation factor G; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SI75.1

    Gene LinkOut

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