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    WRKY4 WRKY DNA-binding protein 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837956, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WRKY4
    Official Full Name
    WRKY DNA-binding protein 4
    Primary source
    TAIR:AT1G13960
    Locus tag
    AT1G13960
    See related
    Araport:AT1G13960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F16A14.18; WRKY DNA-binding protein 4
    Summary
    Encodes WRKY DNA-binding protein 4 (WRKY4).
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    Genomic context

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    See WRKY4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (4776283..4779420)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene eukaryotic elongation factor 5A-1 Neighboring gene beta-hexosaminidase (DUF1336) Neighboring gene sec7 domain-containing protein Neighboring gene plant/protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis for sequence-specific DNA recognition by an Arabidopsis WRKY transcription factor. Yamasaki K, et al. J Biol Chem, 2012 Mar 2. PMID 22219184, Free PMC Article
    2. Solution structure of an Arabidopsis WRKY DNA binding domain. Yamasaki K, et al. Plant Cell, 2005 Mar. PMID 15705956, Free PMC Article
    3. CRISPR/Cas9-mediated mutagenesis of WRKY3 and WRKY4 function decreases salt and Me-JA stress tolerance in Arabidopsis thaliana. Li P, et al. Mol Biol Rep, 2021 Aug. PMID 34351541
    4. Roles of Arabidopsis WRKY3 and WRKY4 transcription factors in plant responses to pathogens. Lai Z, et al. BMC Plant Biol, 2008 Jun 20. PMID 18570649, Free PMC Article
    5. Proteomic analyses identify a diverse array of nuclear processes affected by small ubiquitin-like modifier conjugation in Arabidopsis. Miller MJ, et al. Proc Natl Acad Sci U S A, 2010 Sep 21. PMID 20813957, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRISPR/Cas9-mediated mutagenesis of WRKY3 and WRKY4 function decreases salt and Me-JA stress tolerance in Arabidopsis thaliana.
      Title: CRISPR/Cas9-mediated mutagenesis of WRKY3 and WRKY4 function decreases salt and Me-JA stress tolerance in Arabidopsis thaliana.
    2. Data support that WRKY4 function as transcription factors, have a positive role in plant resistance to necrotrophic pathogens , and has a negative effect on plant resistance to biotrophic pathogens.
      Title: Roles of Arabidopsis WRKY3 and WRKY4 transcription factors in plant responses to pathogens.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001332105.1
    NM_101262.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ethylene IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to jasmonic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to salicylic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    WRKY DNA-binding protein 4
    NP_001318999.1
    • WRKY DNA-binding protein 4 (WRKY4); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: DNA-binding WRKY (InterPro:IPR003657); BEST Arabidopsis thaliana protein match is: WRKY DNA-binding protein 3 (TAIR:AT2G03340.1); Has 5891 Blast hits to 3196 proteins in 226 species: Archae - 0; Bacteria - 0; Metazoa - 44; Fungi - 6; Plants - 5778; Viruses - 0; Other Eukaryotes - 63 (source: NCBI BLink).
    NP_172849.1
    • WRKY DNA-binding protein 4 (WRKY4); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: DNA-binding WRKY (InterPro:IPR003657); BEST Arabidopsis thaliana protein match is: WRKY DNA-binding protein 3 (TAIR:AT2G03340.1); Has 5876 Blast hits to 3214 proteins in 234 species: Archae - 0; Bacteria - 0; Metazoa - 44; Fungi - 17; Plants - 5749; Viruses - 0; Other Eukaryotes - 66 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4776283..4779420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101262.3 → NP_172849.1  WRKY DNA-binding protein 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172849.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93WN8, Q9LMG1, Q9XI90
      UniProtKB/TrEMBL
      A0A5S9UAZ3, A0A654EB63
      Conserved Domains (1) summary
      smart00774
      Location:408 → 465
      WRKY; DNA binding domain

    2. NM_001332105.1 → NP_001318999.1  WRKY DNA-binding protein 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2H1ZEB2
      Conserved Domains (1) summary
      smart00774
      Location:255 → 312
      WRKY; DNA binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XI90.2

    Gene LinkOut

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