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    EDS16 ADC synthase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843810, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EDS16
    Official Full Name
    ADC synthase superfamily protein
    Primary source
    TAIR:AT1G74710
    Locus tag
    AT1G74710
    See related
    Araport:AT1G74710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS ISOCHORISMATE SYNTHASE 1; ATICS1; ENHANCED DISEASE SUSCEPTIBILITY TO ERYSIPHE ORONTII 16; F25A4.31; ICS1; ISOCHORISMATE SYNTHASE; ISOCHORISMATE SYNTHASE 1; SALICYLIC ACID INDUCTION DEFICIENT 2; SID2
    Summary
    Encodes a protein with isochorismate synthase activity. Mutants fail to accumulate salicylic acid. Its function may be redundant with that of ICS2 (AT1G18870).
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    Genomic context

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    See EDS16 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (28070295..28074177)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene IQ-domain 31 Neighboring gene tRNAse Z1 Neighboring gene C2 calcium/lipid-binding plant phosphoribosyltransferase family protein Neighboring gene transmembrane protein, putative (DUF1118) Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isochorismate synthase is required to synthesize salicylic acid for plant defence. Wildermuth MC, et al. Nature, 2001 Nov 29. PMID 11734859
    2. Enhanced tolerance to a combination of heat stress and drought in Arabidopsis plants deficient in ICS1 is associated with modulation of photosynthetic reaction center proteins. Kumazaki A, et al. Physiol Plant, 2019 Feb. PMID 30051471
    3. Isochorismate synthase 1 is required for thylakoid organization, optimal plastoquinone redox status, and state transitions in Arabidopsis thaliana. Gawroński P, et al. J Exp Bot, 2013 Sep. PMID 23956412, Free PMC Article
    4. Salicylic acid deficiency in NahG transgenic lines and sid2 mutants increases seed yield in the annual plant Arabidopsis thaliana. Abreu ME, et al. J Exp Bot, 2009. PMID 19188277, Free PMC Article
    5. Peroxisomal hydrogen peroxide is coupled to biotic defense responses by ISOCHORISMATE SYNTHASE1 in a daylength-related manner. Chaouch S, et al. Plant Physiol, 2010 Aug. PMID 20543092, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SA and NHP glucosyltransferase UGT76B1 affects plant defense in both SID2- and NPR1-dependent and independent manner.
      Title: SA and NHP glucosyltransferase UGT76B1 affects plant defense in both SID2- and NPR1-dependent and independent manner.
    2. expression induced by loss of CRWN proteins
      Title: Loss of CRWN Nuclear Proteins Induces Cell Death and Salicylic Acid Defense Signaling.
    3. PHB3-ICS1 complexes stabilizes ICS1 to promote salicylic acid production in response to stress.
      Title: PROHIBITIN3 Forms Complexes with ISOCHORISMATE SYNTHASE1 to Regulate Stress-Induced Salicylic Acid Biosynthesis in Arabidopsis.
    4. maintenance of photosynthetic apparatus as well as prevention of excess water loss might enhance the tolerance of sid2-1 plants deficient in ICS1 to a combination of heat stress and drought.
      Title: Enhanced tolerance to a combination of heat stress and drought in Arabidopsis plants deficient in ICS1 is associated with modulation of photosynthetic reaction center proteins.
    5. Data suggest that AtICS1 and AtICS2 (here, expressed as hexahistidine fusion proteins) are Mg2+-dependent with similar temperature optima (ca. 33 C) and similar Km values for chorismate, but reaction rates are greater for AtICS1 than for AtICS2; neither enzyme exhibits isochorismate pyruvate lyase activity.
      Title: The biochemical properties of the two Arabidopsis thaliana isochorismate synthases.
    6. TCP proteins are involved in the orchestrated regulation of ICS1 expression, with TCP8 and TCP9 being verified as major representatives.
      Title: TCP transcription factors are critical for the coordinated regulation of isochorismate synthase 1 expression in Arabidopsis thaliana.
    7. Photosynthetic parameters in the ics1 mutant changed in a manner observed previously for state transition-impaired plants. Deregulation of the redox status of the plastoquinone pool in ics1 showed significant variation depending on the leaf age.
      Title: Isochorismate synthase 1 is required for thylakoid organization, optimal plastoquinone redox status, and state transitions in Arabidopsis thaliana.
    8. WRKY28 specifically binds to the ICS1 promoter in vivo, most probably to one or both binding sites at position -460 and -445 upstream of the transcription start site.
      Title: WRKY transcription factors involved in activation of SA biosynthesis genes.
    9. Lesions driven by intracellular H2O2 require SA synthesis through the isochorismate pathway.
      Title: Peroxisomal hydrogen peroxide is coupled to biotic defense responses by ISOCHORISMATE SYNTHASE1 in a daylength-related manner.
    10. sid2 gene, which encodes for isochorismate synthase, plays a central role in SA biosynthesis during plant development not only in leaves, but also in seeds of A. thaliana.
      Title: Salicylic acid deficiency in NahG transgenic lines and sid2 mutants increases seed yield in the annual plant Arabidopsis thaliana.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Pathways from PubChem

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    General gene information

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    NM_106129.4
    NM_202414.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables isochorismate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables isochorismate synthase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf abscission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phylloquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in salicylic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within salicylic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within salicylic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within systemic acquired resistance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within systemic acquired resistance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ADC synthase superfamily protein
    NP_565090.1
    • ENHANCED DISEASE SUSCEPTIBILITY TO ERYSIPHE ORONTII 16 (EDS16); CONTAINS InterPro DOMAIN/s: Chorismate binding, C-terminal (InterPro:IPR015890), ADC synthase (InterPro:IPR005801), Isochorismate synthase (InterPro:IPR004561); BEST Arabidopsis thaliana protein match is: isochorismate synthase 2 (TAIR:AT1G18870.1); Has 14352 Blast hits to 14347 proteins in 2540 species: Archae - 246; Bacteria - 10586; Metazoa - 5; Fungi - 256; Plants - 213; Viruses - 0; Other Eukaryotes - 3046 (source: NCBI BLink).
    NP_974143.1
    • ENHANCED DISEASE SUSCEPTIBILITY TO ERYSIPHE ORONTII 16 (EDS16); CONTAINS InterPro DOMAIN/s: Chorismate binding, C-terminal (InterPro:IPR015890), ADC synthase (InterPro:IPR005801), Isochorismate synthase (InterPro:IPR004561); BEST Arabidopsis thaliana protein match is: isochorismate synthase 2 (TAIR:AT1G18870.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28070295..28074177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106129.4 → NP_565090.1  ADC synthase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565090.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81522, Q3ECD2, Q9ASQ4, Q9S7H8
      UniProtKB/TrEMBL
      A0A178WE28, A0A5S9WUF0, A0A654EU46
      Conserved Domains (1) summary
      PLN02786
      Location:30 → 566
      PLN02786; isochorismate synthase

    2. NM_202414.1 → NP_974143.1  ADC synthase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974143.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WUF0, A0A654EU46
      Conserved Domains (2) summary
      PLN02786
      Location:30 → 552
      PLN02786; isochorismate synthase
      TIGR00543
      Location:198 → 554
      isochor_syn; isochorismate synthases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S7H8.2

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