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    PDIL2-2 PDI-like 2-2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839355, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PDIL2-2
    Official Full Name
    PDI-like 2-2
    Primary source
    TAIR:AT1G04980
    Locus tag
    AT1G04980
    See related
    Araport:AT1G04980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA PROTEIN DISULFIDE ISOMERASE 10; ATPDI10; ATPDIL2-2; F13M7.3; F13M7_3; PDI-like 2-2; PDI10; PROTEIN DISULFIDE ISOMERASE
    Summary
    Encodes a protein disulfide isomerase-like (PDIL) protein, a member of a multigene family within the thioredoxin (TRX) superfamily. Transcript levels for this gene are up-regulated in response to three different chemical inducers of ER stress (dithiothreitol, beta-mercaptoethanol, and tunicamycin). AtIRE1-2 does not appear to be required for this response, but the atbzip60 mutant has a diminished response.
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    Genomic context

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    See PDIL2-2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (1413644..1416218, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene golgin family A protein (DUF1664) Neighboring gene lipid-binding serum glycoprotein family protein Neighboring gene triacylglycerol lipase-like protein Neighboring gene Zinc finger C-x8-C-x5-C-x3-H type family protein Neighboring gene Phosphotyrosine protein phosphatases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana. Lu DP, et al. Mol Genet Genomics, 2008 Sep. PMID 18574595
    2. Plant-specific ribosome biogenesis factors in Arabidopsis thaliana with essential function in rRNA processing. Palm D, et al. Nucleic Acids Res, 2019 Feb 28. PMID 30576513, Free PMC Article
    3. Arabidopsis cell wall proteome defined using multidimensional protein identification technology. Bayer EM, et al. Proteomics, 2006 Jan. PMID 16287169
    4. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_100376.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to endoplasmic reticulum stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type cell wall HDA PubMed 

    General protein information

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    Preferred Names
    PDI-like 2-2
    NP_171990.3
    • PDI-like 2-2 (PDIL2-2); CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Disulphide isomerase (InterPro:IPR005788), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Thioredoxin-like subdomain (InterPro:IPR006662), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: PDI-like 2-3 (TAIR:AT2G32920.1); Has 36254 Blast hits to 18629 proteins in 2906 species: Archae - 392; Bacteria - 18066; Metazoa - 5792; Fungi - 2053; Plants - 2624; Viruses - 46; Other Eukaryotes - 7281 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      1413644..1416218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100376.5 → NP_171990.3  PDI-like 2-2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171990.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9MAU6
      UniProtKB/TrEMBL
      A0A5S9SNK9, A0A654E758
      Conserved Domains (2) summary
      cd02983
      Location:279 → 408
      P5_C; P5 family, C-terminal redox inactive TRX-like domain; P5 is a protein disulfide isomerase (PDI)-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is ...
      cd03001
      Location:168 → 270
      PDI_a_P5; PDIa family, P5 subfamily; composed of eukaryotic proteins similar to human P5, a PDI-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is located in the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MAU6.2

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