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    CRTISO carotenoid isomerase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837193, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CRTISO
    Official Full Name
    carotenoid isomerase
    Primary source
    TAIR:AT1G06820
    Locus tag
    AT1G06820
    See related
    Araport:AT1G06820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CAROTENOID AND CHLOROPLAST REGULATION 2; carotenoid isomerase; CAROTENOID ISOMERASE; CCR2; F4H5.10; F4H5_10
    Summary
    Encodes carotenoid isomerase. Catalyzes the isomerization of poly-cis-carotenoids to all-trans-carotenoids. Together with PDS and ZDS, CRTiso is required to complete the synthesis of lycopene from phytoene.
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    Genomic context

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    See CRTISO in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (2092946..2096784, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RNA polymerase Rpb7 N-terminal domain-containing protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene endonuclease/glycosyl hydrolase Neighboring gene Glutaredoxin family protein Neighboring gene Leucine-rich repeat protein kinase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the carotenoid isomerase provides insight into carotenoid biosynthesis, prolamellar body formation, and photomorphogenesis. Park H, et al. Plant Cell, 2002 Feb. PMID 11884677, Free PMC Article
    2. Transcriptional control of SET DOMAIN GROUP 8 and CAROTENOID ISOMERASE during Arabidopsis development. Cazzonelli CI, et al. Mol Plant, 2010 Jan. PMID 19952001
    3. Cloning of tangerine from tomato reveals a carotenoid isomerase essential for the production of beta-carotene and xanthophylls in plants. Isaacson T, et al. Plant Cell, 2002 Feb. PMID 11884678, Free PMC Article
    4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study demonstrated that both the CRTISO promoter and open reading frame are necessary for SDG8-mediated expression of CRTISO.
      Title: Transcriptional control of SET DOMAIN GROUP 8 and CAROTENOID ISOMERASE during Arabidopsis development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001331668.1
    NM_001331669.1
    NM_001331670.1
    NM_100559.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables carotenoid isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carotenoid isomerase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables carotenoid isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carotenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within carotenoid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within carotenoid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within etioplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    carotenoid isomerase
    NP_172167.2
    • carotenoid isomerase (CRTISO); CONTAINS InterPro DOMAIN/s: Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal (InterPro:IPR003953), Carotene isomerase (InterPro:IPR014101); BEST Arabidopsis thaliana protein match is: FAD/NAD(P)-binding oxidoreductase family protein (TAIR:AT1G57770.1); Has 6522 Blast hits to 6439 proteins in 939 species: Archae - 207; Bacteria - 2788; Metazoa - 150; Fungi - 77; Plants - 203; Viruses - 0; Other Eukaryotes - 3097 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2092946..2096784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100559.4 → NP_172167.2  carotenoid isomerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172167.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M9Y8
      UniProtKB/TrEMBL
      A0A178WN87, A0A5S9SZI3, A0A654E7L0
      Conserved Domains (1) summary
      cl21454
      Location:78 → 572
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001331669.1 → NP_001322209.1  carotenoid isomerase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WN87, A0A1P8ATC2

    3. NM_001331668.1 → NP_001322208.1  carotenoid isomerase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WN87, A0A1P8ATA5

    4. NM_001331670.1 → NP_001322210.1  carotenoid isomerase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ATE5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M9Y8.2

    Gene LinkOut

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