HMG1 hydroxy methylglutaryl CoA reductase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: HMG1
Official Full Name: hydroxy methylglutaryl CoA reductase 1
Primary source: TAIR:AT1G76490
Locus tag: AT1G76490
See related: Araport:AT1G76490
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 3-HYDROXY-3-METHYLGLUTARYL COA REDUCTASE; 3-HYDROXY-3-METHYLGLUTARYL COA REDUCTASE 1; AtHMGR1; F15M4.1; HMG-COA REDUCTASE; HMGR1; hydroxy methylglutaryl CoA reductase 1; MAD3; miRNA action deficient 3
Summary: Encodes a 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is involved in melavonate biosynthesis and performs the first committed step in isoprenoid biosynthesis. Expression is activated in dark in leaf tissue but not controlled by light in the root (confine
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See HMG1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 4

Sequence:: Chromosome: 1; NC_003070.9 (28695760..28698852)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that AKIN10 phosphorylates and inactivates HMGR; AKIN10 phosphorylates not only conserved Ser577 in active site but also other site/sites in noncatalytic domain of HMGR; inactivation of HMGR by AKIN10 requires interaction of AKIN10 with GRIK1. (AKIN10 = SnRK1 protein kinase; HMGR = hydroxymethylglutaryl-CoA-reductase; GRIK1 = geminivirus Rep-interacting kinase 1)
Title: AKIN10, a representative Arabidopsis SNF1-related protein kinase 1 (SnRK1), phosphorylates and downregulates plant HMG-CoA reductase.
The membrane domain of HMGR contributes to endoplasmic reticulum morphogenesis in plant cells.
Title: Proliferation and Morphogenesis of the Endoplasmic Reticulum Driven by the Membrane Domain of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Plant Cells.
PP2A exerts multilevel control on HMGR through the five-member B'' protein family during normal development and in response to a variety of stress conditions.
Title: Multilevel control of Arabidopsis 3-hydroxy-3-methylglutaryl coenzyme A reductase by protein phosphatase 2A.
HMG1 or HMG2 is required for male gametophyte development.
Title: Complete blockage of the mevalonate pathway results in male gametophyte lethality.
increases essential oil yield in spike lavender
Title: Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia.
Subcellular localization of the expression of the gene in A. thaliana.
Title: Subcellular localization of Arabidopsis 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_106299.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in coenzyme A metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process, mevalonate pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within isoprenoid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within isoprenoid biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within sterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
NOT located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
NOT located_in plastid	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: hydroxy methylglutaryl CoA reductase 1

NP_177775.2

hydroxy methylglutaryl CoA reductase 1 (HMG1); CONTAINS InterPro DOMAIN/s: Hydroxymethylglutaryl-CoA reductase, class I, catalytic (InterPro:IPR004554), Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding (InterPro:IPR009029), Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding (InterPro:IPR009023), Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic (InterPro:IPR002202); BEST Arabidopsis thaliana protein match is: 3-hydroxy-3-methylglutaryl-CoA reductase 2 (TAIR:AT2G17370.1); Has 2212 Blast hits to 2210 proteins in 935 species: Archae - 202; Bacteria - 1018; Metazoa - 225; Fungi - 225; Plants - 266; Viruses - 1; Other Eukaryotes - 275 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

28695760..28698852

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_106299.4 → NP_177775.2 hydroxy methylglutaryl CoA reductase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_177775.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P14891, Q6RW12

UniProtKB/TrEMBL

A0A178W3L3, A0A5S9WUZ6, A0A654ER34

Conserved Domains (1) summary

cd00643
Location:223 → 626

HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)