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    TK1a Thymidine kinase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819971, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TK1a
    Official Full Name
    Thymidine kinase
    Primary source
    TAIR:AT3G07800
    Locus tag
    AT3G07800
    See related
    Araport:AT3G07800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtTK1a; thymidine kinase 1a
    Summary
    Encodes a thymidine kinase that salvages DNA precursors.
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    Genomic context

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    See TK1a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (2489387..2491180, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene potyvirus VPg interacting protein (DUF1423) Neighboring gene DGCR14-like protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene Pectin lyase-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis thaliana thymidine kinase 1a is ubiquitously expressed during development and contributes to confer tolerance to genotoxic stress. Pedroza-García JA, et al. Plant Mol Biol, 2015 Feb. PMID 25537647
    2. Thymidine kinases share a conserved function for nucleotide salvage and play an essential role in Arabidopsis thaliana growth and development. Xu J, et al. New Phytol, 2015 Dec. PMID 26139575
    3. Efficient Replication of the Plastid Genome Requires an Organellar Thymidine Kinase. Le Ret M, et al. Plant Physiol, 2018 Dec. PMID 30305373, Free PMC Article
    4. Two thymidine kinases and one multisubstrate deoxyribonucleoside kinase salvage DNA precursors in Arabidopsis thaliana. Clausen AR, et al. FEBS J, 2012 Oct. PMID 22897443
    5. Thymidine kinase 1 regulatory fine-tuning through tetramer formation. Mutahir Z, et al. FEBS J, 2013 Mar. PMID 23351158

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TK1A is required for efficient chloroplast DNA replication and chloroplast biogenesis.
      Title: Efficient Replication of the Plastid Genome Requires an Organellar Thymidine Kinase.
    2. Findings clarify the specialized function of two TKs in A. thaliana and establish that the [nucleotide] salvage pathway mediated by the kinases is essential for plant growth and development. [AtTK1]
      Title: Thymidine kinases share a conserved function for nucleotide salvage and play an essential role in Arabidopsis thaliana growth and development.
    3. suggest that thymidine kinase 1a contributes to several DNA repair pathways by providing deoxythymidine triphosphate that serve as precursors for DNA repair and to balance deoxyribonucleotides pools
      Title: Arabidopsis thaliana thymidine kinase 1a is ubiquitously expressed during development and contributes to confer tolerance to genotoxic stress.
    4. Data show that thymidine kinase was encoded by AtTK1a (AT3G07800) and (AT5G23070), and deoxyadenosine, deoxyguanosine and deoxycytidine kinase activities were encoded by a single AtdNK (AT1G72040) gene.
      Title: Two thymidine kinases and one multisubstrate deoxyribonucleoside kinase salvage DNA precursors in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111659.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables thymidine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to UV-C IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to UV-C IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Thymidine kinase
    NP_187437.1
    • Thymidine kinase; FUNCTIONS IN: thymidine kinase activity, ATP binding; INVOLVED IN: pyrimidine deoxyribonucleoside interconversion, anaerobic respiration; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thymidine kinase (InterPro:IPR001267), Thymidine kinase, conserved site (InterPro:IPR020633); BEST Arabidopsis thaliana protein match is: Thymidine kinase (TAIR:AT5G23070.1); Has 4049 Blast hits to 4037 proteins in 1500 species: Archae - 38; Bacteria - 2547; Metazoa - 142; Fungi - 7; Plants - 74; Viruses - 356; Other Eukaryotes - 885 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2489387..2491180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111659.4 → NP_187437.1  Thymidine kinase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187437.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LDP6, Q9S750
      UniProtKB/TrEMBL
      A0A178VL17, A0A5S9XA66, A0A654F541
      Conserved Domains (1) summary
      cl23762
      Location:31 → 220
      TK; Thymidine kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S750.1

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