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    PR4 pathogenesis-related 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819632, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PR4
    Official Full Name
    pathogenesis-related 4
    Primary source
    TAIR:AT3G04720
    Locus tag
    AT3G04720
    See related
    Araport:AT3G04720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtPR4; F7O18.21; F7O18_21; HEL; HEVEIN-LIKE; pathogenesis-related 4; PR-4
    Summary
    Encodes a protein similar to the antifungal chitin-binding protein hevein from rubber tree latex. mRNA levels increase in response to ethylene and turnip crinkle virus infection.
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    Genomic context

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    See PR4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (1285425..1286760, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene indoleacetic acid-induced protein 16 Neighboring gene RALF-like 21

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modular structure of HEL protein from Arabidopsis reveals new potential functions for PR-4 proteins. Bertini L, et al. Biol Chem, 2012 Dec. PMID 23460952
    2. Modular structure of HEL protein from Arabidopsis reveals new potential functions for PR-4 proteins. Bertini L, et al. Biol Chem, 2012 Aug 4. PMID 22868784
    3. Regulation of a hevein-like gene in Arabidopsis. Potter S, et al. Mol Plant Microbe Interact, 1993 Nov-Dec. PMID 8118053
    4. Ecological modulation of plant defense via phytochrome control of jasmonate sensitivity. Moreno JE, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19251652, Free PMC Article
    5. Pathogen-associated molecular pattern recognition rather than development of tissue necrosis contributes to bacterial induction of systemic acquired resistance in Arabidopsis. Mishina TE, et al. Plant J, 2007 May. PMID 17419843

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The study reports on the characterization of a class I PR4 vacuolar protein from Arabidopsis, named At HEL.
      Title: Modular structure of HEL protein from Arabidopsis reveals new potential functions for PR-4 proteins.
    2. HEL protein has a modular structure consisting of an N-terminal hevein-like domain (CB-HEL) and a C-terminal domain (CD-HEL) that show a strong antifungal activity.
      Title: Modular structure of HEL protein from Arabidopsis reveals new potential functions for PR-4 proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_111344.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA nuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    NOT enables chitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within defense response to fungus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ethylene IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to herbivore IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to virus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within systemic acquired resistance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    NOT located_in plant-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory vesicle HDA PubMed 

    General protein information

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    Preferred Names
    pathogenesis-related 4
    NP_187123.1
    • pathogenesis-related 4 (PR4); FUNCTIONS IN: chitin binding; INVOLVED IN: in 6 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Barwin (InterPro:IPR001153), Glycoside hydrolase, family 19, catalytic (InterPro:IPR000726), Barwin-related endoglucanase (InterPro:IPR009009), Chitin-binding, type 1, conserved site (InterPro:IPR018371), Barwin-like endoglucanase (InterPro:IPR014733), Barwin, conserved site (InterPro:IPR018226), Chitin-binding, type 1 (InterPro:IPR001002); BEST Arabidopsis thaliana protein match is: basic chitinase (TAIR:AT3G12500.1); Has 1702 Blast hits to 1458 proteins in 199 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 253; Plants - 1414; Viruses - 10; Other Eukaryotes - 25 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1285425..1286760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111344.6 → NP_187123.1  pathogenesis-related 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187123.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P43082
      UniProtKB/TrEMBL
      A0A178VMU7, A0A5S9X944, Q8H7F8
      Conserved Domains (2) summary
      cd00035
      Location:32 → 63
      ChtBD1; Hevein or type 1 chitin binding domain
      pfam00967
      Location:76 → 191
      Barwin; Barwin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43082.1

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