HST homogentisate prenyltransferase [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: HST
Official Full Name: homogentisate prenyltransferase
Primary source: TAIR:AT3G11945
Locus tag: AT3G11945
See related: Araport:AT3G11945
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATHST; homogentisate prenyltransferase; PDS2; PHYTOENE DESATURATION 2
Summary: Encodes a protein involved in plastoquinone-9 biosynthesis. The enzyme possesses homogentisate prenyltransferase activity and was shown to use solanesyl diphosphate, farnesyl diphosphate and geranylgeranyldiphosphate as prenyl donors, but not phytyldiphosphate. This gene At3g11945 derives from a split of At3g11950, publications Tian et al (2007) and Sadre et al (2006) refer to this gene as At3g11950.
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Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

HST is essential for chloroplast development, hormone biosynthesis, pigment accumulation and plant development
Title: Disruption of the homogentisate solanesyltransferase gene results in albino and dwarf phenotypes and root, trichome and stomata defects in Arabidopsis thaliana.
VTE2-2 is a conserved gene that encodes a homogentisate phytyltransferase paralog and is involved in tocopherol biosynthesis. [VTE2-2]
Title: Identification and characterization of an Arabidopsis homogentisate phytyltransferase paralog.

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NM_001084669.2

NM_001161137.1

Function	Evidence Code	Pubs
enables dimethylallyltranstransferase activity	NAS Non-traceable Author Statement more info
enables homogentisate farnesyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables homogentisate geranylgeranyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables homogentisate solanesyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables homogentisate solanesyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carotenoid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plastoquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in plastid	HDA more info	PubMed

NP_001078138.1

homogentisate prenyltransferase (HST); FUNCTIONS IN: homogentisate geranylgeranyltransferase activity, homogentisate farnesyltransferase activity, dimethylallyltranstransferase activity, homogentisate solanesyltransferase activity; INVOLVED IN: carotenoid biosynthetic process, plastoquinone biosynthetic process; LOCATED IN: chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: UbiA prenyltransferase (InterPro:IPR000537); BEST Arabidopsis thaliana protein match is: homogentisate phytyltransferase 1 (TAIR:AT2G18950.1); Has 1360 Blast hits to 1357 proteins in 372 species: Archae - 250; Bacteria - 602; Metazoa - 1; Fungi - 4; Plants - 187; Viruses - 0; Other Eukaryotes - 316 (source: NCBI BLink).

NP_001154609.1

homogentisate prenyltransferase (HST); CONTAINS InterPro DOMAIN/s: UbiA prenyltransferase (InterPro:IPR000537); BEST Arabidopsis thaliana protein match is: homogentisate phytyltransferase 1 (TAIR:AT2G18950.1); Has 1367 Blast hits to 1364 proteins in 371 species: Archae - 252; Bacteria - 598; Metazoa - 1; Fungi - 4; Plants - 199; Viruses - 0; Other Eukaryotes - 313 (source: NCBI BLink).