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    ACLB-1 ATP-citrate lyase B-1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819845, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACLB-1
    Official Full Name
    ATP-citrate lyase B-1
    Primary source
    TAIR:AT3G06650
    Locus tag
    AT3G06650
    See related
    Araport:AT3G06650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATP-citrate lyase B-1; T8E24.7; T8E24_7
    Summary
    One of the two genes encoding subunit B of the trimeric enzyme ATP Citrate lyase
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    Genomic context

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    See ACLB-1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Sequence:
    Chromosome: 3; NC_003074.8 (2079033..2083472, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein kinase family protein Neighboring gene PAS domain-containing protein tyrosine kinase family protein Neighboring gene fip1 motif-containing protein Neighboring gene Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein Neighboring gene AGAMOUS-like 91

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a heteromeric ATP-citrate lyase that generates cytosolic acetyl-coenzyme A in Arabidopsis. Fatland BL, et al. Plant Physiol, 2002 Oct. PMID 12376641, Free PMC Article
    2. Proteomic analysis of the 26S proteasome reveals its direct interaction with transit peptides of plastid protein precursors for their degradation. Sako K, et al. J Proteome Res, 2014 Jul 3. PMID 24846764
    3. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    4. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001337675.1
    NM_111541.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP citrate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within acetyl-CoA biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATP-dependent citrate lyase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    ATP-citrate lyase B-1
    NP_187317.1
    • ATP-citrate lyase B-1 (ACLB-1); FUNCTIONS IN: ATP citrate synthase activity; INVOLVED IN: acetyl-CoA biosynthetic process; LOCATED IN: citrate lyase complex, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Succinyl-CoA synthetase, beta subunit, conserved site (InterPro:IPR017866), Citrate synthase-like, small alpha subdomain (InterPro:IPR016143), Succinyl-CoA ligase, alpha subunit (InterPro:IPR005810), ATP-citrate lyase/succinyl-CoA ligase (InterPro:IPR005811), NAD(P)-binding domain (InterPro:IPR016040), CoA-binding (InterPro:IPR003781), Citrate synthase-like, core (InterPro:IPR016141), ATP-citrate lyase/succinyl-CoA ligase, active site (InterPro:IPR017440), Citrate synthase-like (InterPro:IPR002020), Succinyl-CoA synthetase-like (InterPro:IPR016102); BEST Arabidopsis thaliana protein match is: ATP citrate lyase subunit B 2 (TAIR:AT5G49460.1); Has 8069 Blast hits to 8065 proteins in 2074 species: Archae - 271; Bacteria - 4029; Metazoa - 557; Fungi - 289; Plants - 162; Viruses - 0; Other Eukaryotes - 2761 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2079033..2083472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111541.4 → NP_187317.1  ATP-citrate lyase B-1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187317.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C522
      UniProtKB/TrEMBL
      A0A178V742, A0A5S9X9R7, A0A7G2FJB4
      Conserved Domains (1) summary
      PLN02522
      Location:1 → 608
      PLN02522; ATP citrate (pro-S)-lyase

    2. NM_001337675.1 → NP_001326324.1  ATP-citrate lyase B-1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C522
      UniProtKB/TrEMBL
      A0A178V742, A0A5S9X9R7, A0A7G2FJB4
      Conserved Domains (1) summary
      PLN02522
      Location:1 → 608
      PLN02522; ATP citrate (pro-S)-lyase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C522.1

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