DELTA-TIP delta tonoplast integral protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: DELTA-TIP
Official Full Name: delta tonoplast integral protein
Primary source: TAIR:AT3G16240
Locus tag: AT3G16240
See related: Araport:AT3G16240
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AQP1; ATTIP2;1; delta tonoplast integral protein; DELTA-TIP1; TIP2;1
Summary: Delta tonoplast intrinsic protein, functions as a water channel and ammonium (NH3) transporter. Highly expressed in flower, shoot, and stem. Expression shows diurnal regulation and is induced by ammonium (NH3). Protein localized to vacuolar membrane.
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Genomic context

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See DELTA-TIP in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 3

Sequence:: Chromosome: 3; NC_003074.8 (5505360..5507050)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the highly abundant tonoplast aquaporins (AQPs) isoforms AtTIP1;1, AtTIP1;2, and AtTIP2;1 facilitate the emergence of new lateral root primordia (LRPs).
Title: Tonoplast Aquaporins Facilitate Lateral Root Emergence.
The relatively wide pore and the polar nature of the selectivity filter clarify the ammonia permeability.
Title: Crystal Structure of an Ammonia-Permeable Aquaporin.
unlike for TIP1;1, trafficking of markers for TIP3;1 and TIP2;1 is insensitive to Brefeldin A in Arabidopsis hypocotyls
Title: A small molecule inhibitor partitions two distinct pathways for trafficking of tonoplast intrinsic proteins in Arabidopsis.
AtTIP2;1 and AtTIP2;3 can mediate the extracytosolic transport of methyl-NH2 and NH3 across the tonoplast membrane and may thus participate in vacuolar ammonium compartmentation. [TIP2;1]
Title: Tonoplast intrinsic proteins AtTIP2;1 and AtTIP2;3 facilitate NH3 transport into the vacuole.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_112495.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ammonium channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables methylammonium transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables urea transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables water channel activity	IDA Inferred from Direct Assay more info	PubMed
enables water channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within urea transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within water transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in central vacuole	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast envelope	HDA more info	PubMed
located_in plant-type cell wall	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plant-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed
located_in protein storage vacuole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: delta tonoplast integral protein

NP_188245.1

delta tonoplast integral protein (DELTA-TIP); FUNCTIONS IN: water channel activity, ammonia transmembrane transporter activity, urea transmembrane transporter activity, methylammonium transmembrane transporter activity; INVOLVED IN: transport, urea transport, water transport; LOCATED IN: in 10 components; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Major intrinsic protein, conserved site (InterPro:IPR022357), Aquaporin (InterPro:IPR012269), Major intrinsic protein (InterPro:IPR000425); BEST Arabidopsis thaliana protein match is: tonoplast intrinsic protein 2;3 (TAIR:AT5G47450.1); Has 10937 Blast hits to 10900 proteins in 2182 species: Archae - 87; Bacteria - 5160; Metazoa - 1503; Fungi - 423; Plants - 2497; Viruses - 0; Other Eukaryotes - 1267 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

5505360..5507050

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_112495.4 → NP_188245.1 delta tonoplast integral protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_188245.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WM76, Q41951, Q42200, Q42201, Q43352, Q8VZ81

UniProtKB/TrEMBL

A0A5S9XCT4, A0A654FHA0

Conserved Domains (1) summary

cl00200
Location:1 → 244

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...