ERF1 ethylene response factor 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ERF1
Official Full Name: ethylene response factor 1
Primary source: TAIR:AT3G23240
Locus tag: AT3G23240
See related: Araport:AT3G23240
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtERF#092; ATERF1; ERF1B; ethylene response factor 1; ETHYLENE RESPONSE FACTOR 1
Summary: encodes a member of the ERF (ethylene response factor) subfamily B-3 of ERF/AP2 transcription factor family (ERF1). The protein contains one AP2 domain. There are 18 members in this subfamily including ATERF-1, ATERF-2, AND ATERF-5. EREBP like protein that binds GCC box of ethylene regulated promoters such as basic chitinases. Constitutive expression of ERF1 phenocopies ethylene over production. Involved in ethylene signaling cascade,downstream of EIN2 and EIN3.
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Genomic context

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See ERF1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 1

Sequence:: Chromosome: 3; NC_003074.8 (8295617..8296604)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

COP1-ERF1-SCE1 regulatory module fine-tunes stress response under light-dark cycle in Arabidopsis.
Title: COP1-ERF1-SCE1 regulatory module fine-tunes stress response under light-dark cycle in Arabidopsis.
ERF1 inhibits lateral root emergence by promoting local auxin accumulation and repressing ARF7 expression.
Title: ERF1 inhibits lateral root emergence by promoting local auxin accumulation and repressing ARF7 expression.
NIGT1.4 maintains primary root elongation in response to salt stress through induction of ERF1 in Arabidopsis.
Title: NIGT1.4 maintains primary root elongation in response to salt stress through induction of ERF1 in Arabidopsis.
ERF1 delays flowering through direct inhibition of FLOWERING LOCUS T expression in Arabidopsis.
Title: ERF1 delays flowering through direct inhibition of FLOWERING LOCUS T expression in Arabidopsis.
UBC18 negatively regulated drought and salt stress responses by altering the abundance of ERF1 and the expression of genes downstream of ERF1.
Title: UBC18 mediates ERF1 degradation under light-dark cycles.
Using loss- and gain-of-function transgenic lines as well as biochemical analysis, we demonstrate that ERF1 can directly up-regulate ASA1 by binding to its promoter, leading to auxin accumulation and ethylene-induced inhibition of root growth.
Title: Arabidopsis ERF1 Mediates Cross-Talk between Ethylene and Auxin Biosynthesis during Primary Root Elongation by Regulating ASA1 Expression.
Results provide evidence that AtERF1 is important for regulating AtNudt7 during oxidative signaling.
Title: A GCC-box motif in the promoter of nudix hydrolase 7 (AtNUDT7) gene plays a role in ozone response of Arabidopsis ecotypes.
Expression of several ethylene biosynthetic genes and ethylene-responsive factors, including ERF1 and ERF2, was induced during reoxygenation.
Title: Ethylene plays an essential role in the recovery of Arabidopsis during post-anaerobiosis reoxygenation.
ERF1 plays a positive role in salt, drought, and heat stress tolerance by stress-specific gene regulation, which integrates jasmonic acid, ethylene, and abscisic acid signals.
Title: The Arabidopsis ETHYLENE RESPONSE FACTOR1 regulates abiotic stress-responsive gene expression by binding to different cis-acting elements in response to different stress signals.
High- and medium-affinity binding sites are over-represented in promoters of MYC2- or ERF1-regulated genes, and therefore they may represent new cis-regulatory elements.
Title: Improved protein-binding microarrays for the identification of DNA-binding specificities of transcription factors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_113225.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ethylene-activated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ethylene-activated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within jasmonic acid mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in intracellular anatomical structure	TAS Traceable Author Statement more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: ethylene response factor 1

NP_188965.1

ethylene response factor 1 (ERF1); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: ethylene-responsive element binding factor 15 (TAIR:AT2G31230.1); Has 5944 Blast hits to 5682 proteins in 249 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 5925; Viruses - 2; Other Eukaryotes - 17 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

8295617..8296604

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_113225.3 → NP_188965.1 ethylene response factor 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_188965.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LDC8, Q9ZNR2

UniProtKB/TrEMBL

A0A178VAI9, A0A7G2ERE3

Conserved Domains (1) summary

smart00380
Location:81 → 138

AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs