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    SERAT2;2 serine acetyltransferase 2;2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820499, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SERAT2;2
    Official Full Name
    serine acetyltransferase 2;2
    Primary source
    TAIR:AT3G13110
    Locus tag
    AT3G13110
    See related
    Araport:AT3G13110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSERAT2;2; SAT-1; SAT-A; SAT-M; SAT3; serine acetyltransferase 2;2; SERINE ACETYLTRANSFERASE 3; SERINE ACETYLTRANSFERASE A; SERINE ACETYLTRANSFERASE-1; SERINE ACETYLTRANSFERASE-MITOCHONDRIAL
    Summary
    Encodes a mitochondrial serine O-acetyltransferase involved in sulfur assimilation and cysteine biosynthesis. Expressed in the vascular system.
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    Genomic context

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    See SERAT2;2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (4214399..4216302, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene multidrug resistance-associated protein 8 Neighboring gene miscRNA Neighboring gene multidrug resistance-associated protein 7 Neighboring gene Ribosomal protein S10p/S20e family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial serine acetyltransferase functions as a pacemaker of cysteine synthesis in plant cells. Haas FH, et al. Plant Physiol, 2008 Oct. PMID 18753283, Free PMC Article
    2. Mitochondrial cysteine synthase complex regulates O-acetylserine biosynthesis in plants. Wirtz M, et al. J Biol Chem, 2012 Aug 10. PMID 22730323, Free PMC Article
    3. Allosterically gated enzyme dynamics in the cysteine synthase complex regulate cysteine biosynthesis in Arabidopsis thaliana. Feldman-Salit A, et al. Structure, 2012 Feb 8. PMID 22325778
    4. Use of biomolecular interaction analysis to elucidate the regulatory mechanism of the cysteine synthase complex from Arabidopsis thaliana. Berkowitz O, et al. J Biol Chem, 2002 Aug 23. PMID 12063244
    5. The cysteine synthase complex from plants. Mitochondrial serine acetyltransferase from Arabidopsis thaliana carries a bifunctional domain for catalysis and protein-protein interaction. Wirtz M, et al. Eur J Biochem, 2001 Feb. PMID 11168407

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitochondrial SERAT2;2 plays a predominant role in cellular OAS formation.
      Title: Comparative genomics and reverse genetics analysis reveal indispensable functions of the serine acetyltransferase gene family in Arabidopsis.
    2. Mitochondrial serine acetyltransferase regulates the production of O-acetylserine in the mitochondria, which affects cysteine synthesis.
      Title: Mitochondrial serine acetyltransferase functions as a pacemaker of cysteine synthesis in plant cells.
    3. From the results of sensitivity to feedback regulation, subcellular localization and expression of mRNA analyses, each serine acetyltransferase (SATase) isoform seems to have its specific role for cysteine biosynthesis.
      Title: In silico assessment of gene function involved in cysteine biosynthesis in Arabidopsis: expression analysis of multiple isoforms of serine acetyltransferase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_112150.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine O-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine O-acetyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables zinc ion binding HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cysteine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cysteine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine acetyltransferase 2;2
    NP_187918.1
    • serine acetyltransferase 2;2 (SERAT2;2); FUNCTIONS IN: zinc ion binding, serine O-acetyltransferase activity; INVOLVED IN: response to cadmium ion, cysteine biosynthetic process; LOCATED IN: mitochondrion; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Hexapeptide transferase, conserved site (InterPro:IPR018357), Serine O-acetyltransferase (InterPro:IPR005881), Trimeric LpxA-like (InterPro:IPR011004), Serine acetyltransferase, N-terminal (InterPro:IPR010493); BEST Arabidopsis thaliana protein match is: serine acetyltransferase 2;1 (TAIR:AT1G55920.1); Has 25521 Blast hits to 25511 proteins in 2666 species: Archae - 387; Bacteria - 19255; Metazoa - 8; Fungi - 225; Plants - 240; Viruses - 18; Other Eukaryotes - 5388 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4214399..4216302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112150.4 → NP_187918.1  serine acetyltransferase 2;2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187918.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0V7U9, Q0WWV4, Q39218, Q42532, Q43739, Q43740, Q7DLZ8, Q7DM01
      UniProtKB/TrEMBL
      A0A178VHI8, A0A5S9XBN0, A0A654F8B1
      Conserved Domains (1) summary
      PLN02357
      Location:17 → 391
      PLN02357; serine acetyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39218.3

    Gene LinkOut

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