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    MNS2 alpha-mannosidase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821668, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MNS2
    Official Full Name
    alpha-mannosidase 2
    Primary source
    TAIR:AT3G21160
    Locus tag
    AT3G21160
    See related
    Araport:AT3G21160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    alpha-mannosidase 2; ALPHA-MANNOSIDASE IA; MANIA; MSA6.31
    Summary
    Encodes an alpha-mannosidase I enzyme responsible for N-glycan maturation.
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    Genomic context

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    See MNS2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Sequence:
    Chromosome: 3; NC_003074.8 (7413776..7418484, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene Pyridoxamine 5'-phosphate oxidase family protein Neighboring gene B-box 32 Neighboring gene F-box/associated interaction domain protein Neighboring gene F-box/associated interaction domain protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two Arabidopsis thaliana Golgi alpha-mannosidase I enzymes are responsible for plant N-glycan maturation. Kajiura H, et al. Glycobiology, 2010 Feb. PMID 19914916
    2. Trimming of N-Glycans by the Golgi-Localized α-1,2-Mannosidases, MNS1 and MNS2, Is Crucial for Maintaining RSW2 Protein Abundance during Salt Stress in Arabidopsis. Liu C, et al. Mol Plant, 2018 May 7. PMID 29409894
    3. Class I alpha-mannosidases are required for N-glycan processing and root development in Arabidopsis thaliana. Liebminger E, et al. Plant Cell, 2009 Dec. PMID 20023195, Free PMC Article
    4. Identification of proteins that interact with catalytically active calcium-dependent protein kinases from Arabidopsis. Uno Y, et al. Mol Genet Genomics, 2009 Apr. PMID 19130088
    5. Separating Golgi Proteins from Cis to Trans Reveals Underlying Properties of Cisternal Localization. Parsons HT, et al. Plant Cell, 2019 Sep. PMID 31266899, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MNS1/2-mediated mannose trimming of N-glycans is crucial in modulating glycoprotein abundance to withstand salt stress in plants
      Title: Trimming of N-Glycans by the Golgi-Localized α-1,2-Mannosidases, MNS1 and MNS2, Is Crucial for Maintaining RSW2 Protein Abundance during Salt Stress in Arabidopsis.
    2. data indicate that either AtMANIa or AtMANIb can function as the Golgi alpha-mannosidase I that produces the Man(5)GlcNAc(2) N-glycan structure necessary for complex N-glycan synthesis. [MANIa]
      Title: Two Arabidopsis thaliana Golgi alpha-mannosidase I enzymes are responsible for plant N-glycan maturation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001338506.1
    NM_113010.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within N-glycan processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within N-glycan processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within root development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in Golgi cis cisterna HDA PubMed 
    located_in endosome HDA PubMed 
    located_in trans-Golgi network HDA PubMed 

    General protein information

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    Preferred Names
    alpha-mannosidase 2
    NP_566675.1
    • alpha-mannosidase 2 (MNS2); CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 47 (InterPro:IPR001382); BEST Arabidopsis thaliana protein match is: alpha-mannosidase 1 (TAIR:AT1G51590.1); Has 2046 Blast hits to 1918 proteins in 195 species: Archae - 0; Bacteria - 11; Metazoa - 790; Fungi - 842; Plants - 175; Viruses - 0; Other Eukaryotes - 228 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7413776..7418484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113010.3 → NP_566675.1  alpha-mannosidase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566675.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8H116, Q94A04, Q9LJB6
      UniProtKB/TrEMBL
      A0A178VCU4
      Conserved Domains (1) summary
      pfam01532
      Location:105 → 537
      Glyco_hydro_47; Glycosyl hydrolase family 47

    2. NM_001338506.1 → NP_001327148.1  alpha-mannosidase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LRE8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H116.1

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