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    CYP90D1 cytochrome P450, family 90, subfamily D, polypeptide 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820582, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP90D1
    Official Full Name
    cytochrome P450, family 90, subfamily D, polypeptide 1
    Primary source
    TAIR:AT3G13730
    Locus tag
    AT3G13730
    See related
    Araport:AT3G13730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''cytochrome P450; cytochrome P450; family 90; polypeptide 1; polypeptide 1''; subfamily D
    Summary
    Encodes a cytochrome P-450 gene that is involved in brassinosteroid biosynthesis, most likely in the conversion step of teasterone (TE) to 3-dehydroteasterone (3DT), and/or 6-deoxoteasterone (6-deoxoTE) to 6-deoxo-3-dehydroteasterone (6-deoxo3DT); or the conversion of cathasterone (CT) to TE, and/or 6-deoxocathasterone (6-deoxoCT) to 6-deoxoTE. Recently, CYP90D1 was shown to catalyse the C-23 hydroxylation of several brassinosteroids (the enzyme has a broad specificity for 22-hydroxylated substrates). Member of the CYP90C CYP450 family. Similar to Cytochrome P450 90C1 (ROT3).
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    Genomic context

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    See CYP90D1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (4497893..4500920, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene prenylated RAB acceptor 1.F4 Neighboring gene PRA1 (Prenylated rab acceptor) family protein Neighboring gene ncRNA Neighboring gene Ribonuclease III family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C-23 hydroxylation by Arabidopsis CYP90C1 and CYP90D1 reveals a novel shortcut in brassinosteroid biosynthesis. Ohnishi T, et al. Plant Cell, 2006 Nov. PMID 17138693, Free PMC Article
    2. CYP90C1 and CYP90D1 are involved in different steps in the brassinosteroid biosynthesis pathway in Arabidopsis thaliana. Kim GT, et al. Plant J, 2005 Mar. PMID 15703058
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In vitro biochemical assays using insect cell-expressed proteins revealed that both CYP90C1 and CYP90D1 catalyze C-23 hydroxylation of various 22-hydroxylated Brassinosteroids with markedly different catalytic efficiencies.
      Title: C-23 hydroxylation by Arabidopsis CYP90C1 and CYP90D1 reveals a novel shortcut in brassinosteroid biosynthesis.
    2. CYP90D1 is involved in brassinosteroid biosynthesis pathway. [CYP90D1]
      Title: CYP90C1 and CYP90D1 are involved in different steps in the brassinosteroid biosynthesis pathway in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001338068.1
    NM_112223.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 22alpha-hydroxysteroid 23-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brassinosteroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within brassinosteroid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within petal development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within stamen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 90, subfamily D, polypeptide 1
    NP_566462.1
    • ''cytochrome P450, family 90, subfamily D, polypeptide 1'' (CYP90D1); FUNCTIONS IN: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen, oxygen binding; INVOLVED IN: stamen development, petal development, leaf development, brassinosteroid biosynthetic process; LOCATED IN: endomembrane system; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: Cytochrome P450 superfamily protein (TAIR:AT4G36380.1); Has 27722 Blast hits to 27661 proteins in 1582 species: Archae - 80; Bacteria - 4717; Metazoa - 10119; Fungi - 4209; Plants - 7293; Viruses - 6; Other Eukaryotes - 1298 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4497893..4500920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112223.3 → NP_566462.1  cytochrome P450, family 90, subfamily D, polypeptide 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566462.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94IA6, Q9LIC5
      UniProtKB/TrEMBL
      A0A178VDZ8, A0A5S9XBU6
      Conserved Domains (1) summary
      PLN03141
      Location:44 → 491
      PLN03141; 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional

    2. NM_001338068.1 → NP_001327080.1  cytochrome P450, family 90, subfamily D, polypeptide 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VBI6, A0A1I9LR77, A0A384L4N6, A0A5S9XBU6
      Conserved Domains (1) summary
      PLN03141
      Location:44 → 464
      PLN03141; 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94IA6.1

    Gene LinkOut

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