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    CLC-B chloride channel B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822336, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CLC-B
    Official Full Name
    chloride channel B
    Primary source
    TAIR:AT3G27170
    Locus tag
    AT3G27170
    See related
    Araport:AT3G27170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCLC-B; chloride channel B
    Summary
    member of Anion channel protein family
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    Genomic context

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    See CLC-B in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (10023931..10027198)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene Ribosomal protein S21 family protein Neighboring gene ncRNA Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene ncRNA Neighboring gene cyclin B1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CHLORIDE CHANNEL-b mediates vacuolar nitrate efflux to improve low nitrogen adaptation in Arabidopsis. Shi Y, et al. Plant Physiol, 2023 Oct 26. PMID 37527482
    2. CLC-b-mediated NO-3/H+ exchange across the tonoplast of Arabidopsis vacuoles. von der Fecht-Bartenbach J, et al. Plant Cell Physiol, 2010 Jun. PMID 20430762
    3. Overexpression of PP2A-C5 that encodes the catalytic subunit 5 of protein phosphatase 2A in Arabidopsis confers better root and shoot development under salt conditions. Hu R, et al. Plant Cell Environ, 2017 Jan. PMID 27676158
    4. A family of putative chloride channels from Arabidopsis and functional complementation of a yeast strain with a CLC gene disruption. Hechenberger M, et al. J Biol Chem, 1996 Dec 27. PMID 8969232
    5. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CHLORIDE CHANNEL-b mediates vacuolar nitrate efflux to improve low nitrogen adaptation in Arabidopsis.
      Title: CHLORIDE CHANNEL-b mediates vacuolar nitrate efflux to improve low nitrogen adaptation in Arabidopsis.
    2. CLC-b was localized at the tonoplast, and conducted strongly outwardly rectifying anionic currents that were largest in the presence of nitrate.
      Title: CLC-b-mediated NO-3/H+ exchange across the tonoplast of Arabidopsis vacuoles.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_113631.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables monoatomic anion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nitrate:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables voltage-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular anatomical structure TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chloride channel B
    NP_189353.1
    • chloride channel B (CLC-B); FUNCTIONS IN: nitrate:hydrogen symporter activity, anion channel activity, voltage-gated chloride channel activity; INVOLVED IN: chloride transport, transmembrane transport; LOCATED IN: plant-type vacuole membrane, intracellular; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Chloride channel, core (InterPro:IPR014743), Chloride channel, voltage gated (InterPro:IPR001807), Chloride channel ClC-plant (InterPro:IPR002251), Cystathionine beta-synthase, core (InterPro:IPR000644); BEST Arabidopsis thaliana protein match is: chloride channel A (TAIR:AT5G40890.1); Has 6974 Blast hits to 6653 proteins in 1746 species: Archae - 129; Bacteria - 4490; Metazoa - 970; Fungi - 341; Plants - 365; Viruses - 0; Other Eukaryotes - 679 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      10023931..10027198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113631.4 → NP_189353.1  chloride channel B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189353.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P92942
      UniProtKB/TrEMBL
      A0A178VKG6, A0A5S9XG68, A0A7G2EQ20
      Conserved Domains (2) summary
      cd03685
      Location:54 → 575
      ClC_6_like; ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes. This family ...
      cd04591
      Location:595 → 762
      CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P92942.1

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