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    B ALPHA protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841594, updated on 18-Sep-2024

    Summary

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    Official Symbol
    B ALPHA
    Official Full Name
    protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
    Primary source
    TAIR:AT1G51690
    Locus tag
    AT1G51690
    See related
    Araport:AT1G51690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATB ALPHA; F19C24.10; F19C24_10; protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
    Summary
    55 kDa B regulatory subunit of phosphatase 2A mRNA
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    Genomic context

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    See B ALPHA in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (19163843..19170449)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 4 Neighboring gene uncharacterized protein Neighboring gene 4-coumarate:CoA ligase 1 Neighboring gene ncRNA Neighboring gene DOF zinc finger protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. B-family subunits of protein phosphatase 2A are necessary for pollen development but not for female gametophyte development in Arabidopsis. Tsugama D, et al. Biochem Biophys Res Commun, 2018 Oct 20. PMID 30243715
    2. Antagonistic regulation of flowering time through distinct regulatory subunits of protein phosphatase 2A. Heidari B, et al. PLoS One, 2013. PMID 23976921, Free PMC Article
    3. Protein phosphatase 2A B55 and A regulatory subunits interact with nitrate reductase and are essential for nitrate reductase activation. Heidari B, et al. Plant Physiol, 2011 May. PMID 21436382, Free PMC Article
    4. Distinct Clades of Protein Phosphatase 2A Regulatory B'/B56 Subunits Engage in Different Physiological Processes. Heidari B, et al. Int J Mol Sci, 2023 Jul 31. PMID 37569631, Free PMC Article
    5. ROTUNDA3 function in plant development by phosphatase 2A-mediated regulation of auxin transporter recycling. Karampelias M, et al. Proc Natl Acad Sci U S A, 2016 Mar 8. PMID 26888284, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct Clades of Protein Phosphatase 2A Regulatory B'/B56 Subunits Engage in Different Physiological Processes.
      Title: Distinct Clades of Protein Phosphatase 2A Regulatory B'/B56 Subunits Engage in Different Physiological Processes.
    2. Data suggest that the B subunit of protein phosphatase 2A (PP2A) ATBA and ATBB play pleiotropic roles in pollen development.
      Title: B-family subunits of protein phosphatase 2A are necessary for pollen development but not for female gametophyte development in Arabidopsis.
    3. Mutants homozygous for mutation in Bbeta and heterozygous for mutation in Balpha revealed a slower activation rate for nitrate reductase (NR) than wild-type plants, pointing to these subunits as part of a PP2A complex responsible for NR dephosphorylation.
      Title: Protein phosphatase 2A B55 and A regulatory subunits interact with nitrate reductase and are essential for nitrate reductase activation.
    4. The results showed that PP2A-B55 is a negative regulator of flowering.
      Title: Antagonistic regulation of flowering time through distinct regulatory subunits of protein phosphatase 2A.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001198270.1
    NM_202274.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
    NP_001185199.1
    • protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (B ALPHA); FUNCTIONS IN: nucleotide binding, protein phosphatase type 2A regulator activity; INVOLVED IN: signal transduction; LOCATED IN: endomembrane system, protein phosphatase type 2A complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat-like-containing domain (InterPro:IPR011046), Protein phosphatase 2A, regulatory subunit PR55 (InterPro:IPR000009), Protein phosphatase 2A, regulatory subunit PR55, conserved site (InterPro:IPR018067), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Protein phosphatase 2A, regulatory subunit PR55 (TAIR:AT1G17720.2).
    NP_564595.1
    • protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (B ALPHA); FUNCTIONS IN: nucleotide binding, protein phosphatase type 2A regulator activity; INVOLVED IN: signal transduction; LOCATED IN: protein phosphatase type 2A complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat-like-containing domain (InterPro:IPR011046), Protein phosphatase 2A, regulatory subunit PR55 (InterPro:IPR000009), Protein phosphatase 2A, regulatory subunit PR55, conserved site (InterPro:IPR018067), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Protein phosphatase 2A, regulatory subunit PR55 (TAIR:AT1G17720.1); Has 958 Blast hits to 924 proteins in 264 species: Archae - 0; Bacteria - 26; Metazoa - 505; Fungi - 177; Plants - 117; Viruses - 0; Other Eukaryotes - 133 (source: NCBI BLink).
    NP_974003.1
    • protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (B ALPHA); FUNCTIONS IN: nucleotide binding, protein phosphatase type 2A regulator activity; INVOLVED IN: signal transduction; LOCATED IN: protein phosphatase type 2A complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat-like-containing domain (InterPro:IPR011046), Protein phosphatase 2A, regulatory subunit PR55 (InterPro:IPR000009), Protein phosphatase 2A, regulatory subunit PR55, conserved site (InterPro:IPR018067), WD40 repeat, conserved site (InterPro:IPR019775), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Protein phosphatase 2A, regulatory subunit PR55 (TAIR:AT1G17720.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19163843..19170449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104047.4 → NP_564595.1  protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564595.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WL96, Q27GN0, Q38821, Q8L842, Q9C8H8
      UniProtKB/TrEMBL
      A0A654EHJ3
      Conserved Domains (2) summary
      COG5170
      Location:19 → 513
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:237 → 276
      7WD40; WD40 repeat [structural motif]

    2. NM_001333494.1 → NP_001322512.1  protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WL96, Q27GN0, Q38821, Q8L842, Q9C8H8
      UniProtKB/TrEMBL
      A0A654EHJ3
      Conserved Domains (2) summary
      COG5170
      Location:19 → 513
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:237 → 276
      7WD40; WD40 repeat [structural motif]

    3. NM_001333495.1 → NP_001322511.1  protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AUA0

    4. NM_001198270.1 → NP_001185199.1  protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185199.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4I9M3
      Conserved Domains (3) summary
      COG5170
      Location:110 → 603
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:327 → 366
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:130 → 516
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. NM_202274.2 → NP_974003.1  protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974003.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WBC1, A0A5S9WP29
      Conserved Domains (2) summary
      COG5170
      Location:19 → 512
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:236 → 275
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38821.2

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