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    SIP4 SOS3-interacting protein 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817586, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SIP4
    Official Full Name
    SOS3-interacting protein 4
    Primary source
    TAIR:AT2G30360
    Locus tag
    AT2G30360
    See related
    Araport:AT2G30360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CBL-INTERACTING PROTEIN KINASE 11; CIPK11; PKS5; PROTEIN KINASE SOS2-LIKE 5; SNF1-RELATED PROTEIN KINASE 3.22; SNRK3.22; SOS3-interacting protein 4; T9D9.17; T9D9_17
    Summary
    Encodes a SOS2-like protein kinase that is a member of the CBL-interacting protein kinase family.Loss of function mutants show a decrease in sensitivity to high pH.Phosphorylates AHA2, a plasma membrane H+ ATPase.This phosphorylation appears to regulate the activity of the proton transporter.
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    Genomic context

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    See SIP4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (12936968..12938834, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene LOB domain-containing protein 13 Neighboring gene Excinuclease ABC, C subunit, N-terminal Neighboring gene ncRNA Neighboring gene allergen-like protein Neighboring gene ncRNA Neighboring gene MYB family transcription factor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The kinase CIPK11 functions as a positive regulator in cadmium stress response in Arabidopsis. Gu S, et al. Gene, 2021 Mar 10. PMID 33346096
    2. The Kinase CIPK11 Functions as a Negative Regulator in Drought Stress Response in Arabidopsis. Ma Y, et al. Int J Mol Sci, 2019 May 16. PMID 31100788, Free PMC Article
    3. The alkaline tolerance in Arabidopsis requires stabilizing microfilament partially through inactivation of PKS5 kinase. Liu J, et al. J Genet Genomics, 2011 Jul 20. PMID 21777855
    4. The Arabidopsis chaperone J3 regulates the plasma membrane H+-ATPase through interaction with the PKS5 kinase. Yang Y, et al. Plant Cell, 2010 Apr. PMID 20418496, Free PMC Article
    5. Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance. Yang Z, et al. Nat Commun, 2019 Mar 13. PMID 30867421, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The kinase CIPK11 functions as a positive regulator in cadmium stress response in Arabidopsis.
      Title: The kinase CIPK11 functions as a positive regulator in cadmium stress response in Arabidopsis.
    2. The overexpression of CIPK11 (CIPK11OE) in Arabidopsis resulted in the decreased tolerance of plant to drought stress. CIPK11 partly mediates the drought stress response by regulating the transcription factor Di19-3.
      Title: The Kinase CIPK11 Functions as a Negative Regulator in Drought Stress Response in Arabidopsis.
    3. propose that Ca(2+)-triggered CBL1/9-mediated activation of CIPK11 and subsequent phosphorylation of FIT shifts inactive into active FIT, allowing regulatory protein interactions in the nucleus
      Title: CIPK11-Dependent Phosphorylation Modulates FIT Activity to Promote Arabidopsis Iron Acquisition in Response to Calcium Signaling.
    4. SOS2-LIKE PROTEIN KINASE5 (PKS5) can negatively regulate the Salt-Overly-Sensitive signaling pathway in Arabidopsis. PKS5 can interact with and phosphorylate SOS2 at Ser294, promote the interaction between SOS2 and 14-3-3 proteins, and repress SOS2 activity. However, salt stress promotes an interaction between 14-3-3 proteins and PKS5, repressing its kinase activity and releasing inhibition of SOS2.
      Title: Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance.
    5. PKS5-mediated phosphorylation of ABI5 at Ser-42 is critical for the abscissic acid regulation of seed germination and gene expression in Arabidopsis.
      Title: SOS2-LIKE PROTEIN KINASE5, an SNF1-RELATED PROTEIN KINASE3-Type Protein Kinase, Is Important for Abscisic Acid Responses in Arabidopsis through Phosphorylation of ABSCISIC ACID-INSENSITIVE5.
    6. PKS5 involves in external high pH signal mediated microfilament depolymerization, and that may be independent of calcium signal.
      Title: The alkaline tolerance in Arabidopsis requires stabilizing microfilament partially through inactivation of PKS5 kinase.
    7. results suggest that PKS5 functions at the upstream of NPR1 and might mediate expression of WRKY38 and WRKY62 possibly by interacting with and phosphorylating NPR1.
      Title: PKS5, a SNF1-related kinase, interacts with and phosphorylates NPR1, and modulates expression of WRKY38 and WRKY62.
    8. J3 regulates plasma membrane H+-ATPase activity through interaction with the PKS5 kinase.
      Title: The Arabidopsis chaperone J3 regulates the plasma membrane H+-ATPase through interaction with the PKS5 kinase.
    9. These results suggest that PKS5 is part of a calcium-signaling pathway mediating PM H+ -ATPase regulation.
      Title: Arabidopsis protein kinase PKS5 inhibits the plasma membrane H+ -ATPase by preventing interaction with 14-3-3 protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_128589.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in abscisic acid-activated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within abscisic acid-activated signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to calcium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SOS3-interacting protein 4
    NP_180595.1
    • SOS3-interacting protein 4 (SIP4); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), NAF domain (InterPro:IPR004041), CBL-interacting protein kinase (InterPro:IPR020660), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: serine/threonine protein kinase 1 (TAIR:AT5G01820.1); Has 132389 Blast hits to 130226 proteins in 4650 species: Archae - 184; Bacteria - 15582; Metazoa - 48520; Fungi - 13393; Plants - 32054; Viruses - 541; Other Eukaryotes - 22115 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      12936968..12938834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128589.2 → NP_180595.1  SOS3-interacting protein 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180595.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22932, Q7FYB7, Q944I6
      UniProtKB/TrEMBL
      A0A178W0H8, A0A5S9X2L0, A0A654F869
      Conserved Domains (2) summary
      cd12195
      Location:308 → 421
      CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases
      cl21453
      Location:20 → 276
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22932.1

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