JLO Lateral organ boundaries (LOB) domain family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: JLO
Official Full Name: Lateral organ boundaries (LOB) domain family protein
Primary source: TAIR:AT4G00220
Locus tag: AT4G00220
See related: Araport:AT4G00220
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F6N15.4; F6N15_4; JAGGED LATERAL ORGANS; LBD30; LOB DOMAIN-CONTAINING PROTEIN 30
Summary: Encodes a protein containing a LOB domain that is expressed in embryos, flower primordium and lateral floral organ boundaries. Overexpression is correlated with activation of STM and KNAT1 and down regulation of PIN1 and reduced auxin transport levels. Ectopic expression in plants results in premature termination of the shoot apical meristem and small, lobed leaves. A maternally expressed imprinted gene.
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Genomic context

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See JLO in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 2

Sequence:: Chromosome: 4; NC_003075.7 (89908..92255)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genes controlling SCW formation were activated by the overexpression of LBD30, but not in the LBD30(K226R) mutant. LBD30 enhancement of SCW formation resulted from upregulation of SND1/NST1-mediated transcriptional networks. This study presents a mechanism by which sumoylation of LBD30, mediated by SIZ1, regulates SCW formation in A. thaliana.
Title: SUMO modification of LBD30 by SIZ1 regulates secondary cell wall formation in Arabidopsis thaliana.
JLO can regulate auxin perception and consequently auxin transport and auxin-responsive gene expression
Title: The Arabidopsis JAGGED LATERAL ORGANS (JLO) gene sensitizes plants to auxin.
Data indicate that the transcript levels of HAK5 and four transcriptin factor genes DDF2, JLO, bHLH121 and TFII_A were highly up-regulated in response to both -K and salt stress.
Title: Identification and characterization of transcription factors regulating Arabidopsis HAK5.
The JLO and AS2 proteins interact molecularly and form multimeric complexes with AS1 to suppress KNOX expression. AS2 together with JLO regulate auxin transport in seedling roots.
Title: Arabidopsis JAGGED LATERAL ORGANS acts with ASYMMETRIC LEAVES2 to coordinate KNOX and PIN expression in shoot and root meristems.
JLO is a central regulator of auxin distribution and signaling throughout plant development.
Title: JAGGED LATERAL ORGAN (JLO) controls auxin dependent patterning during development of the Arabidopsis embryo and root.
ASL19 were expressed in immature tracheary elements (TEs), and the expression was dependent on VASCULAR-RELATED NAC-DOMAIN PROTEIN6 (VND6) and VND7, which are transcription factors required for TE differentiation.
Title: ASYMMETRIC LEAVES2-LIKE19/LATERAL ORGAN BOUNDARIES DOMAIN30 and ASL20/LBD18 regulate tracheary element differentiation in Arabidopsis.
Jagged Lateral Organs (JLO) acts from the boundary to orchestrate the drastic changes in gene expression that entail the initiation of plant lateral organs. [JLO]
Title: Arabidopsis JAGGED LATERAL ORGANS is expressed in boundaries and coordinates KNOX and PIN activity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_116239.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within organ boundary specification between lateral organs and the meristem	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within xylem development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Lateral organ boundaries (LOB) domain family protein

NP_191933.1

JAGGED LATERAL ORGANS (JLO); CONTAINS InterPro DOMAIN/s: Lateral organ boundaries, LOB (InterPro:IPR004883); BEST Arabidopsis thaliana protein match is: LOB domain-containing protein 18 (TAIR:AT2G45420.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

89908..92255

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_116239.4 → NP_191933.1 Lateral organ boundaries (LOB) domain family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_191933.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0MF43, B7XG73, O81323, Q1PED1

UniProtKB/TrEMBL

A0A178UUM7, A0A5S9XP82

Conserved Domains (1) summary

pfam03195
Location:20 → 116

LOB; Lateral organ boundaries (LOB) domain