KEA3 K+ efflux antiporter 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: KEA3
Official Full Name: K+ efflux antiporter 3
Primary source: TAIR:AT4G04850
Locus tag: AT4G04850
See related: Araport:AT4G04850
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATKEA3; K+ efflux antiporter 3; T4B21.3; T4B21_3
Summary: member of Putative potassium transporter family
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Genomic context

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See KEA3 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 18

Sequence:: Chromosome: 4; NC_003075.7 (2452664..2457767)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Modification of Activity of the Thylakoid H(+)/K(+) Antiporter KEA3 Disturbs pH-Dependent Regulation of Photosynthesis.
Title: Modification of Activity of the Thylakoid H(+)/K(+) Antiporter KEA3 Disturbs ∆pH-Dependent Regulation of Photosynthesis.
Double mutations in the plastid K(+) exchange antiporter (KEA) transporters kea1kea2 and a single mutation that does not visibly affect chloroplast structure, kea3, impaired the rapid hyperosmotic-induced Ca(2+) responses.
Title: Rapid hyperosmotic-induced Ca2+ responses in Arabidopsis thaliana exhibit sensory potentiation and involvement of plastidial KEA transporters.
Findings suggest that fine regulation of K+ efflux antiporter KEA3 activity is necessary for optimizing photosynthesis.
Title: Fine-tuned regulation of the K(+) /H(+) antiporter KEA3 is required to optimize photosynthesis during induction.
KEA3 activity is regulated by a mechanism involving its lumen-localized C-terminus, which lowers KEA3 activity in high light.
Title: Regulation and Levels of the Thylakoid K+/H+ Antiporter KEA3 Shape the Dynamic Response of Photosynthesis in Fluctuating Light.
KEA3 is critical for high photosynthetic efficiency under fluctuating light.
Title: Ion antiport accelerates photosynthetic acclimation in fluctuating light environments.
role of inner envelope KEA1 and KEA2 and thylakoid KEA3 transporters in chloroplast osmoregulation, integrity, and ion and pH homeostasis
Title: Plastidial transporters KEA1, -2, and -3 are essential for chloroplast osmoregulation, integrity, and pH regulation in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_116723.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables potassium ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium:proton antiporter activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chloroplast organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within nonphotochemical quenching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photosynthetic acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of photosynthesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of photosynthesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect regulation of cellular hyperosmotic salinity response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of photosynthesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to high light intensity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast thylakoid membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in thylakoid membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: K+ efflux antiporter 3

NP_001190675.1

K+ efflux antiporter 3 (KEA3); FUNCTIONS IN: potassium:hydrogen antiporter activity, potassium ion transmembrane transporter activity; INVOLVED IN: potassium ion transport, cation transport, metabolic process, transmembrane transport; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cation/H+ exchanger (InterPro:IPR006153), NAD(P)-binding domain (InterPro:IPR016040), Regulator of K+ conductance, N-terminal (InterPro:IPR003148); BEST Arabidopsis thaliana protein match is: K+ efflux antiporter 1 (TAIR:AT1G01790.1).

NP_567272.4

K+ efflux antiporter 3 (KEA3); FUNCTIONS IN: potassium:hydrogen antiporter activity, potassium ion transmembrane transporter activity; INVOLVED IN: potassium ion transport, cation transport, metabolic process, transmembrane transport; LOCATED IN: chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cation/H+ exchanger (InterPro:IPR006153), NAD(P)-binding domain (InterPro:IPR016040), Regulator of K+ conductance, N-terminal (InterPro:IPR003148); BEST Arabidopsis thaliana protein match is: K+ efflux antiporter 1 (TAIR:AT1G01790.1); Has 8794 Blast hits to 8786 proteins in 1953 species: Archae - 296; Bacteria - 7320; Metazoa - 54; Fungi - 26; Plants - 301; Viruses - 0; Other Eukaryotes - 797 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

2452664..2457767

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001203746.1 → NP_001190675.1 K+ efflux antiporter 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190675.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0N9DZS1, F4JGY3, Q9M0Z3, Q9ZS89

UniProtKB/TrEMBL

A0A5S9XPU4, A0A654FLT3

Conserved Domains (2) summary

COG0475
Location:106 → 515

KefB; Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]

pfam02254
Location:527 → 648

TrkA_N; TrkA-N domain
NM_116723.5 → NP_567272.4 K+ efflux antiporter 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567272.4

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9XPU4, A0A654FLT3

Conserved Domains (2) summary

COG0475
Location:106 → 515

KefB; Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]

cl21454
Location:527 → 622

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins