U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ATK5 kinesin 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825867, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ATK5
    Official Full Name
    kinesin 5
    Primary source
    TAIR:AT4G05190
    Locus tag
    AT4G05190
    See related
    Araport:AT4G05190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    C17L7.110; C17L7_110; kinesin 5
    Summary
    ATK5 encodes a kinesin protein involved in microtubule spindle morphogenesis. It acts as a minus-end directed motor as well as a plus-end tracking protein (+TIP). Localizes to mitotic spindle midzones and regions rich in growing plus-ends within phragmoplasts.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ATK5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Sequence:
    Chromosome: 4; NC_003075.7 (2675064..2680214)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene photosystem II subunit Q-2 Neighboring gene cysteine-rich RLK (RECEPTOR-like protein kinase) 25 Neighboring gene Trimeric LpxA-like enzymes superfamily protein Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene Ubiquitin-like superfamily protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The kinesin ATK5 functions in early spindle assembly in Arabidopsis. Ambrose JC, et al. Plant Cell, 2007 Jan. PMID 17220198, Free PMC Article
    2. A minus-end-directed kinesin with plus-end tracking protein activity is involved in spindle morphogenesis. Ambrose JC, et al. Mol Biol Cell, 2005 Apr. PMID 15659646, Free PMC Article
    3. Functional divergence of the duplicated AtKIN14a and AtKIN14b genes: critical roles in Arabidopsis meiosis and gametophyte development. Quan L, et al. Plant J, 2008 Mar. PMID 18088313
    4. A conserved role for kinesin-5 in plant mitosis. Bannigan A, et al. J Cell Sci, 2007 Aug 15. PMID 17652157
    5. Analysis of the Arabidopsis nuclear proteome and its response to cold stress. Bae MS, et al. Plant J, 2003 Dec. PMID 14617066

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis AtKIN14a and AtKIN14b genes encoding highly similar kinesins are two of the most closely related Arabidopsis paralogs. They together play important roles in controlling plant reproductive development. [AtKIN14b]
      Title: Functional divergence of the duplicated AtKIN14a and AtKIN14b genes: critical roles in Arabidopsis meiosis and gametophyte development.
    2. These results are among the first reports of any motor with a major role in anastral spindle structure in plants and demonstrate that the conservation of kinesin-5 motor function throughout eukaryotes extends to vascular plants.
      Title: A conserved role for kinesin-5 in plant mitosis.
    3. ATK5 participates in the search and capture of antiparallel interpolar microtubules, where it aids in generating force to coalign microtubules, thereby affecting spindle length, width, and integrity.
      Title: The kinesin ATK5 functions in early spindle assembly in Arabidopsis.
    4. ATK5 uses plus-end tracking to reach spindle midzones, where it then organizes microtubules via minus-end-directed motor activity [ATK5]
      Title: A minus-end-directed kinesin with plus-end tracking protein activity is involved in spindle morphogenesis.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help
    NM_001340542.1
    NM_116758.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    kinesin 5
    NP_192428.2
    • kinesin 5 (ATK5); FUNCTIONS IN: microtubule motor activity; INVOLVED IN: spindle assembly, microtubule cytoskeleton organization; LOCATED IN: spindle microtubule, nucleus; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: kinesin 1 (TAIR:AT4G21270.1); Has 92441 Blast hits to 53030 proteins in 2518 species: Archae - 977; Bacteria - 10764; Metazoa - 46004; Fungi - 8189; Plants - 5583; Viruses - 252; Other Eukaryotes - 20672 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      2675064..2680214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116758.4 → NP_192428.2  kinesin 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192428.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JGP4, Q0WP75, Q6NQ77, Q9M0X6
      UniProtKB/TrEMBL
      A0A5S9XPR8
      Conserved Domains (4) summary
      smart00129
      Location:428 → 772
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1340
      Location:150 → 414
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd01366
      Location:426 → 771
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam16043
      Location:106 → 211
      DUF4795; Domain of unknown function (DUF4795)

    2. NM_001340542.1 → NP_001329202.1  kinesin 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B702, A0A5S9XPR8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JGP4.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.