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    pyruvate carrier-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825927, updated on 18-Sep-2024

    Summary

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    Official Full Name
    pyruvate carrier-like protein
    Primary source
    TAIR:AT4G05590
    Locus tag
    AT4G05590
    See related
    Araport:AT4G05590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F6H8.10; F6H8_10; Negative Regulator of Guard Cell ABA Signaling 1; NRGA1
    Summary
    Encodes NRGA1, a putative mitochondrial pyruvate carrier that mediates ABA regulation of guard cell ion channels and drought stress responses.
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (2907012..2908631)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial pyruvate carrier 1 mediates abscisic acid-regulated stomatal closure and the drought response by affecting cellular pyruvate content in Arabidopsis thaliana. Shen JL, et al. BMC Plant Biol, 2017 Nov 22. PMID 29166881, Free PMC Article
    2. NRGA1, a putative mitochondrial pyruvate carrier, mediates ABA regulation of guard cell ion channels and drought stress responses in Arabidopsis. Li CL, et al. Mol Plant, 2014 Oct. PMID 24842572
    3. Mitochondrial Pyruvate Carriers Prevent Cadmium Toxicity by Sustaining the TCA Cycle and Glutathione Synthesis. He L, et al. Plant Physiol, 2019 May. PMID 30770461, Free PMC Article
    4. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NRGA1 role in the cadmium tolerance in Arabidopsis.
      Title: Mitochondrial Pyruvate Carriers Prevent Cadmium Toxicity by Sustaining the TCA Cycle and Glutathione Synthesis.
    2. The Arabidopsis thaliana gene NRGA1 is a putative mitochondrial pyruvate carrier which negatively regulates abscissic acid-induced guard cell signaling.[NRGA1]
      Title: NRGA1, a putative mitochondrial pyruvate carrier, mediates ABA regulation of guard cell ion channels and drought stress responses in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001036510.3
    NM_001340557.1
    NM_116797.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial pyruvate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial pyruvate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyruvate carrier-like protein
    NP_001031587.1
    • CONTAINS InterPro DOMAIN/s: Uncharacterised protein family UPF0041 (InterPro:IPR005336); BEST Arabidopsis thaliana protein match is: Uncharacterised protein family (UPF0041) (TAIR:AT4G22310.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_567306.1
    • CONTAINS InterPro DOMAIN/s: Uncharacterised protein family UPF0041 (InterPro:IPR005336); BEST Arabidopsis thaliana protein match is: Uncharacterised protein family (UPF0041) (TAIR:AT4G22310.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      2907012..2908631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116797.4 → NP_567306.1  pyruvate carrier-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567306.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84VZ9, Q8LD38, Q9M0U5
      UniProtKB/TrEMBL
      A0A178UZ36, A0A5S9XRX0
      Conserved Domains (1) summary
      pfam03650
      Location:5 → 97
      MPC; Uncharacterized protein family (UPF0041)

    2. NM_001340557.1 → NP_001329913.1  pyruvate carrier-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B966
      Conserved Domains (1) summary
      pfam03650
      Location:5 → 69
      MPC; Uncharacterized protein family (UPF0041)

    3. NM_001036510.3 → NP_001031587.1  pyruvate carrier-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031587.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LD38
      Conserved Domains (1) summary
      pfam03650
      Location:5 → 135
      MPC; uncharacterized protein family (UPF0041)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LD38.1

    Gene LinkOut

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