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    SMO1-2 sterol C4-methyl oxidase 1-2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828374, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SMO1-2
    Official Full Name
    sterol C4-methyl oxidase 1-2
    Primary source
    TAIR:AT4G22756
    Locus tag
    AT4G22756
    See related
    Araport:AT4G22756
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSMO1; ATSMO1-2; SMO1; STEROL 4-ALPHA-METHYL-OXIDASE 1; STEROL C4-METHYL OXIDASE 1; sterol C4-methyl oxidase 1-2
    Summary
    Encodes a member of the SMO1 family of sterol 4alpha-methyl oxidases. More specifically functions as a 4,4-dimethyl-9beta,19-cyclopropylsterol-4alpha- methyl oxidase.
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    Genomic context

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    See SMO1-2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (11954840..11956918, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene methylsterol monooxygenase 1-3 Neighboring gene tRNA-Lys Neighboring gene PPR containing protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The SMO1 Family of Sterol 4α-Methyl Oxidases Is Essential for Auxin- and Cytokinin-Regulated Embryogenesis. Song J, et al. Plant Physiol, 2019 Oct. PMID 31341004, Free PMC Article
    2. Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors. Lung SC, et al. New Phytol, 2018 Apr. PMID 29288621
    3. Plant sterol biosynthesis: identification of two distinct families of sterol 4alpha-methyl oxidases. Darnet S, et al. Biochem J, 2004 Mar 15. PMID 14653780, Free PMC Article
    4. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The SMO1 Family of Sterol 4alpha-Methyl Oxidases Is Essential for Auxin- and Cytokinin-Regulated Embryogenesis.
      Title: The SMO1 Family of Sterol 4α-Methyl Oxidases Is Essential for Auxin- and Cytokinin-Regulated Embryogenesis.
    2. ACBP1 was demonstrated to co-express and interact with SMO1-2.
      Title: Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_118404.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables C-4 methylsterol oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables C-4 methylsterol oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within 4,4-dimethyl-9beta,19-cyclopropylsterol oxidation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in fatty acid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sterol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sterol C4-methyl oxidase 1-2
    NP_567670.1
    • sterol C4-methyl oxidase 1-2 (SMO1-2); FUNCTIONS IN: C-4 methylsterol oxidase activity, 4,4-dimethyl-9beta,19-cyclopropylsterol-4alpha-methyl oxidase activity, catalytic activity; INVOLVED IN: sterol biosynthetic process; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694); BEST Arabidopsis thaliana protein match is: sterol-4alpha-methyl oxidase 1-1 (TAIR:AT4G12110.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11954840..11956918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118404.5 → NP_567670.1  sterol C4-methyl oxidase 1-2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567670.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1EC69, Q8GT72, Q8LAD9
      UniProtKB/TrEMBL
      A0A178V1A7, A0A7G2F4P7
      Conserved Domains (1) summary
      pfam04116
      Location:132 → 267
      FA_hydroxylase; Fatty acid hydroxylase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1EC69.1

    Gene LinkOut

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