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    SGT1A phosphatase-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828457, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SGT1A
    Official Full Name
    phosphatase-like protein
    Primary source
    TAIR:AT4G23570
    Locus tag
    AT4G23570
    See related
    Araport:AT4G23570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F9D16.40; F9D16_40
    Summary
    Closely related to SGT1B, may function in SCF(TIR1) mediated protein degradation. AtSGT1a and AtSGT1b are functionally redundant in the resistance to pathogenes. AtSGT1b was more highly expressed than AtSGT1. The N-terminal TPR domain of AtSGT1a reduces the steady-state level of Arabidopsis SGT1 proteins whereas the same domain from AtSGT1b enhances SGT1 accumulation. The TPR domain is dispensable for SGT1 resistance. AtSGT1a is induced upon pathogen infection and can function in R gene-mediated resistance.
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    Genomic context

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    See SGT1A in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (12299749..12302935)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene WRKY family transcription factor Neighboring gene glycosyl hydrolase 9B15 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulatory role of SGT1 in early R gene-mediated plant defenses. Austin MJ, et al. Science, 2002 Mar 15. PMID 11847308
    2. Role of SGT1 in resistance protein accumulation in plant immunity. Azevedo C, et al. EMBO J, 2006 May 3. PMID 16619029, Free PMC Article
    3. SRFR1 negatively regulates plant NB-LRR resistance protein accumulation to prevent autoimmunity. Li Y, et al. PLoS Pathog, 2010 Sep 16. PMID 20862316, Free PMC Article
    4. The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance. Azevedo C, et al. Science, 2002 Mar 15. PMID 11847307
    5. Structural and functional analysis of SGT1 reveals that its interaction with HSP90 is required for the accumulation of Rx, an R protein involved in plant immunity. Botër M, et al. Plant Cell, 2007 Nov. PMID 18032631, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuclear magnetic resonance spectroscopy and mutational analyses of HSP90 revealed the nature of its binding with the CS domain of SGT1.
      Title: Structural and functional analysis of SGT1-HSP90 core complex required for innate immunity in plants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036627.2
    NM_118488.6
    NM_179098.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to auxin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    phosphatase-like protein
    NP_001031704.1
    • SGT1A; CONTAINS InterPro DOMAIN/s: CS-like domain (InterPro:IPR007052), Tetratricopeptide-like helical (InterPro:IPR011990), SGS (InterPro:IPR007699), Tetratricopeptide repeat-containing (InterPro:IPR013026), HSP20-like chaperone (InterPro:IPR008978), Tetratricopeptide repeat (InterPro:IPR019734), CS domain (InterPro:IPR017447); BEST Arabidopsis thaliana protein match is: phosphatase-related (TAIR:AT4G11260.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_194088.1
    • SGT1A; FUNCTIONS IN: protein binding; INVOLVED IN: defense response, ubiquitin-dependent protein catabolic process, embryo development ending in seed dormancy; LOCATED IN: SCF ubiquitin ligase complex, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), SGS (InterPro:IPR007699), HSP20-like chaperone (InterPro:IPR008978), CS domain (InterPro:IPR017447), CS-like domain (InterPro:IPR007052), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: phosphatase-related (TAIR:AT4G11260.1); Has 12440 Blast hits to 8629 proteins in 714 species: Archae - 442; Bacteria - 3949; Metazoa - 2875; Fungi - 1120; Plants - 1288; Viruses - 0; Other Eukaryotes - 2766 (source: NCBI BLink).
    NP_849429.1
    • SGT1A; FUNCTIONS IN: protein binding; INVOLVED IN: defense response, ubiquitin-dependent protein catabolic process, embryo development ending in seed dormancy; LOCATED IN: SCF ubiquitin ligase complex, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), SGS (InterPro:IPR007699), HSP20-like chaperone (InterPro:IPR008978), CS domain (InterPro:IPR017447), CS-like domain (InterPro:IPR007052), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: phosphatase-related (TAIR:AT4G11260.1); Has 12440 Blast hits to 8629 proteins in 714 species: Archae - 442; Bacteria - 3949; Metazoa - 2875; Fungi - 1120; Plants - 1288; Viruses - 0; Other Eukaryotes - 2766 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12299749..12302935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179098.3 → NP_849429.1  phosphatase-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849429.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84LL4, Q8W515, Q9SUR9
      UniProtKB/TrEMBL
      A0A178UUN8
      Conserved Domains (5) summary
      cd06466
      Location:155 → 238
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      PLN03088
      Location:1 → 350
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:35 → 65
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:36 → 68
      TPR_1; Tetratricopeptide repeat
      pfam05002
      Location:268 → 348
      SGS; SGS domain

    2. NM_118488.6 → NP_194088.1  phosphatase-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194088.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84LL4, Q8W515, Q9SUR9
      UniProtKB/TrEMBL
      A0A178UUN8
      Conserved Domains (5) summary
      cd06466
      Location:155 → 238
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      PLN03088
      Location:1 → 350
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:35 → 65
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:36 → 68
      TPR_1; Tetratricopeptide repeat
      pfam05002
      Location:268 → 348
      SGS; SGS domain

    3. NM_001036627.2 → NP_001031704.1  phosphatase-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031704.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XVM6, A0A654FSC1
      Conserved Domains (4) summary
      cd06466
      Location:156 → 239
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      PLN03088
      Location:1 → 351
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:35 → 66
      TPR; TPR repeat [structural motif]
      pfam05002
      Location:269 → 349
      SGS; SGS domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SUR9.1

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