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    LACS4 AMP-dependent synthetase and ligase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828484, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LACS4
    Official Full Name
    AMP-dependent synthetase and ligase family protein
    Primary source
    TAIR:AT4G23850
    Locus tag
    AT4G23850
    See related
    Araport:AT4G23850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    long-chain acyl-CoA synthetase 4; T32A16.20; T32A16_20
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    Genomic context

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    See LACS4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    19
    Sequence:
    Chromosome: 4; NC_003075.7 (12403454..12408421, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene HMG (high mobility group) box protein Neighboring gene WRKY family transcription factor Neighboring gene Pectin lyase-like superfamily protein Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene PHD finger protein-like protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Long chain acyl CoA synthetase 4 catalyzes the first step in peroxisomal indole-3-butyric acid to IAA conversion. Jawahir V, et al. Plant Physiol, 2021 Feb 25. PMID 33631795, Free PMC Article
    2. Two activities of long-chain acyl-coenzyme A synthetase are involved in lipid trafficking between the endoplasmic reticulum and the plastid in Arabidopsis. Jessen D, et al. Plant Physiol, 2015 Feb. PMID 25540329, Free PMC Article
    3. Combined activity of LACS1 and LACS4 is required for proper pollen coat formation in Arabidopsis. Jessen D, et al. Plant J, 2011 Nov. PMID 21790813
    4. Arabidopsis contains nine long-chain acyl-coenzyme a synthetase genes that participate in fatty acid and glycerolipid metabolism. Shockey JM, et al. Plant Physiol, 2002 Aug. PMID 12177484, Free PMC Article
    5. Brassica napus cDNAs encoding fatty acyl-CoA synthetase. Fulda M, et al. Plant Mol Biol, 1997 Mar. PMID 9106514

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The analyses of mutant lines revealed strongly overlapping functions of LACS4 and LACS9 in lipid trafficking from the endoplasmic reticulum to the plastid.
      Title: Two activities of long-chain acyl-coenzyme A synthetase are involved in lipid trafficking between the endoplasmic reticulum and the plastid in Arabidopsis.
    2. The combined inactivation of LACS1 and LACS4 in Arabidopsis resulted in conditional pollen sterility and impaired wax biosynthesis.
      Title: Combined activity of LACS1 and LACS4 is required for proper pollen coat formation in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_118516.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in indolebutyric acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    colocalizes_with peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AMP-dependent synthetase and ligase family protein
    NP_194116.1
    • long-chain acyl-CoA synthetase 4 (LACS4); FUNCTIONS IN: catalytic activity; INVOLVED IN: fatty acid biosynthetic process; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: AMP-dependent synthetase and ligase family protein (TAIR:AT4G11030.1); Has 52797 Blast hits to 49694 proteins in 3271 species: Archae - 966; Bacteria - 33480; Metazoa - 2301; Fungi - 1946; Plants - 2035; Viruses - 1; Other Eukaryotes - 12068 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12403454..12408421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118516.5 → NP_194116.1  AMP-dependent synthetase and ligase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194116.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9T0A0
      UniProtKB/TrEMBL
      A0A178UXP9, A0A5S9XV90
      Conserved Domains (1) summary
      PLN02614
      Location:1 → 666
      PLN02614; long-chain acyl-CoA synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9T0A0.1

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