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    ABCB2 P-glycoprotein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828702, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABCB2
    Official Full Name
    P-glycoprotein 2
    Primary source
    TAIR:AT4G25960
    Locus tag
    AT4G25960
    See related
    Araport:AT4G25960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATP-binding cassette B2; F20B18.70; F20B18_70; P-glycoprotein 2; PGP2
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    Genomic context

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    See ABCB2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    13
    Sequence:
    Chromosome: 4; NC_003075.7 (13177356..13183692)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ENTH/ANTH/VHS superfamily protein Neighboring gene vacuolar ATP synthase G3 Neighboring gene phosphatidylserine decarboxylase 3 Neighboring gene peroxidase superfamily protein Neighboring gene CCT motif family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    2. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_118729.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    P-glycoprotein 2
    NP_194326.2
    • P-glycoprotein 2 (PGP2); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances; INVOLVED IN: transport, transmembrane transport; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: P-glycoprotein 10 (TAIR:AT1G10680.1); Has 857619 Blast hits to 396855 proteins in 4207 species: Archae - 14871; Bacteria - 670687; Metazoa - 17931; Fungi - 12963; Plants - 9451; Viruses - 35; Other Eukaryotes - 131681 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      13177356..13183692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118729.4 → NP_194326.2  P-glycoprotein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194326.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04711, Q0WUR0, Q8LPK2
      UniProtKB/TrEMBL
      A0A654FST2
      Conserved Domains (3) summary
      cd03249
      Location:1030 → 1268
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:76 → 1269
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:86 → 349
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LPK2.3

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